The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision
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Recently, much progress has been made in elucidating the chemistry and metabolism of retinoids and carotenoids, as well as the structures of processing proteins related to vision. Carotenoids and their retinoid metabolites are isoprenoids, so only a limited number of chemical transformations are possible, and just a few of these occur naturally. Although there is an intriguing evolutionary conservation of the key components involved in the production and recycling of chromophores, these genes have also adapted to the specific requirements of insect and vertebrate vision. These 'ancestral footprints' in animal genomes bear witness to the common origin of the chemistry of vision, and will further stimulate research across evolutionary boundaries.
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11-cis-retinal is produced in the RPE and delivered to photoreceptors.
“The photosensitive active retinoid, 11-cis-retinal, is produced in the RPE and delivered to the photoreceptors.”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [83]
Domain B of the IRBP module shares structural similarity with the ligand-binding domain of CRALBP.
“Notably, domain B of the IRBP module shares structural similarity with the ligand-binding domain of CRALBP.83”
From Chemistry of the Retinoid (Visual) Cycle (2014) · cites this paper as [83]
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References 92 · Cited by 119
- Authors
- von Lintig, J., Kiser, P. D., Golczak, M., & Palczewski, K.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Palczewski, Krzysztof
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 35
- Issue
- 7
- Pages
- 400-410
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC2891588
- OpenAlex
- W2133113835
- Cited by
- 119
- References
- 92
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 11
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (EY-008061, R01EY008061, R01EY008123, EY 08123, T32EY007157, P30EY011373)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinoids, trans-to-cis isomerization, vision, carotenoids, terpenoids, rhodopsin, retinol-binding protein, visual pigments, evolution of vision, insect vision, vertebrate vision
- MeSH terms
- Animals, Humans, Retinoids, Stereoisomerism, Molecular Structure
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