The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes
Open accessAbstract
The discovery of natural RNA enzymes (ribozymes) prompted the pursuit of artificial DNA enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual and practical advantages of DNA relative to proteins and RNA. Early studies focused on RNA-cleaving deoxyribozymes, and more recent experiments have expanded the breadth of catalytic DNA to many other reactions. Including modified nucleotides has the potential to widen the scope of DNA enzymes even further. Practical applications of deoxyribozymes include their use as sensors for metal ions and small molecules. Structural studies of deoxyribozymes are just beginning; mechanistic experiments will surely follow. From the first report 21 years ago, the field of deoxyribozymes has promise for both fundamental and applied advances in chemistry, biology, and other disciplines.
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Cites
Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,405
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,812
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E., & Cech, T. R. (1982) · Cell · doi:10.1016/0092-8674(82)90414-7 · Cited by 2,331
Functional Nucleic Acid Sensors
Liu, J., Cao, Z., & Lu, Y. (2009) · Chemical Reviews · doi:10.1021/cr030183i · Cited by 2,187
A general purpose RNA-cleaving DNA enzyme
Santoro, S. W., & Joyce, G. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4262 · Cited by 1,541
Breaker, R. R., & Joyce, G. F. (1994) · Chemistry & Biology · doi:10.1016/1074-5521(94)90014-0 · Cited by 1,476
Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA
Robertson, D. L., & Joyce, G. F. (1990) · Nature · doi:10.1038/344467a0 · Cited by 1,331
Serganov, A., & Nudler, E. (2013) · Cell · doi:10.1016/j.cell.2012.12.024 · Cited by 1,013
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Cited by
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Building machines with DNA molecules
Ramezani, H., & Dietz, H. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0175-6 · Cited by 284
Lake, R. J., Yang, Z., Zhang, J., & Lu, Y. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00419 · Cited by 281
Metadata
- Authors
- Silverman, S. K.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 41
- Issue
- 7
- Pages
- 595-609
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2400468982
- Cited by
- 364
- References
- 108
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
