The Inositol Phosphate Signalling Network in Physiology and Disease
Open accessAbstract
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past decades regarding the biochemical principles and significance of InsP metabolism. We focus on the biological actions of InsPs in mammals, with an emphasis on recent findings regarding specific target proteins. We further discuss the roles of InsP metabolism in contributing to physiological homeostasis and pathological conditions. A deeper understanding of InsPs and their metabolic pathways holds the potential to address unresolved questions and propel advances towards therapeutic applications.
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In the HOIP pathway, IPMK along with ITPK1 plays a crucial role in generating inositol polyphosphates from InsP3.
“In the HOIP pathway (Figure 1B), IPMK, along with Inositol-trisphosphate 3-kinase 1 (ITPK1), plays a crucial role in generating inositol polyphosphates (InsPs) from Inositol 1,4,5-trisphosphate (InsP3) [10,16].”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [16]
In “Synthesis and turnover of InsP6” (page unavailable), the paper says IPMK helps convert Ins(1,4,5)P3 into higher inositol phosphates, but names IP3K—not ITPK1—as the other kinase in that route. It places ITPK1 in a separate pathway that begins with Ins3P, so the claim does not supportably pair ITPK1 with IPMK as acting from Ins(1,4,5)P3. (LLM, conf=0.88)
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Cites
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
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Research works printed but not linked: 17
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“( B ) In the HOIP pathway, Ins(1,4,5)P 3 is generated from PIP 2 via PLC [16].”
Influential
- Authors
- Kim, S., Bhandari, R., Brearley, C. A., & Saiardi, A.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Centre for DNA Fingerprinting and Diagnostics (IN)
- University of East Anglia (GB)
- MRC Laboratory for Molecular Cell Biology (GB)
- Corresponding author
- Kim, Seyun
- Bhandari, Rashna
- Brearley, Charles A.
- Saiardi, Adolfo
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2024-11
- Volume
- 49
- Issue
- 11
- Pages
- 969-985
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W4402740096
- Cited by
- 70
- References
- 1
- Citations by year
- 2026: 28 · 2025: 39 · 2024: 2 · 2020: 1
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Biochemical Sciences (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion, other-oa)
- Funders
- Department of Biotechnology, Ministry of Science and Technology, India (IC-12025(11)/2/2020/ICD-DBT)
- National Research Foundation of Korea (RS-2023-00278918, NRF-2018R1A5A1024261, RS-2024-00415888)
- Natural Environment Research Council (NE/W000350/1)
- Medical Research Council (MR/T028904/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- inositol phosphates, inositol pyrophosphates, inositol phosphate metabolism, signal transduction, homeostasis, disease, therapeutic target
- MeSH terms
- Animals, Humans, Inositol Phosphates, Signal Transduction
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