Therapeutic protein aggregation: mechanisms, design, and control

Cited by (455)

Items 201–300 of 455

1. Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation
   Cesar Calero‐Rubio, Bradford A. Paik, Xinqiao Jia, Kristi Lynn Kiick, Christopher J. Roberts · 2016 · Biophysical Chemistry
2. A general platform for antibody purification utilizing engineered-micelles
   Gunasekaran Dhandapani, Assaf Howard, Thien Van Truong, Thekke V. Baiju, Ellina Kesselman, Noga Friedman, Ellen J. Wachtel, Mordechai Sheves, Dganit Danino, Irishi N. N. Namboothiri et al. · 2019 · mAbs
3. Concentration Effects in the Interaction of Monoclonal Antibodies (mAbs) with their Immediate Environment Characterized by EPR Spectroscopy
   Haleh Hashemi Haeri, Jacob Blaffert, Florian Arndt Schöffmann, Michaela Blech, Josef Hartl, Patrick Garidel, Dariush Hinderberger · 2019 · Molecules
4. Arginine dipeptides affect insulin aggregation in a pH‐ and ionic strength‐dependent manner
   Mariam Nuhu, Robin Curtis · 2015 · Biotechnology Journal
5. An accelerated antibody aggregation test based on time sequenced dynamic light scattering
   Cathryn G. Conner, James J. F. McAndrew, Stefano Menegatti, Orlin D. Velev · 2022 · Colloids and Surfaces A Physicochemical and Engineering Aspects
6. Revolutionizing Synthetic Antibody Design: Harnessing Artificial Intelligence and Deep Sequencing Big Data for Unprecedented Advances
   Eugenio Gallo · 2024 · Molecular Biotechnology
7. Molecular mechanism of protein aggregation inhibition with sulfobetaine polymers and their hydrophobic derivatives
   Robin Rajan, Tadaomi Furuta, Dandan Zhao, Kazuaki Matsumura · 2024 · Cell Reports Physical Science
8. Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models
   Harold W. Hatch, Christina Bergonzo, Marco A. Blanco, Guangcui Yuan, Sergei Grudinin, Mikael Lund, Joseph E. Curtis, Alexander Grishaev, Yun Liu, Vincent K. Shen · 2024 · The Journal of Chemical Physics
9. Leveraging high-throughput analytics and automation to rapidly develop high-concentration mAb formulations: integrated excipient compatibility and viscosity screening
   Lun Xin, Lan Lan, Mourad Mellal, Nathan McChesney, Robert C. Vaughan, Claudia Berdugo, Yunsong Li, Jingtao Zhang · 2024 · Antibody Therapeutics
10. A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein
    Bowen Jiang, Hua Yu, Yongrong Zhang, Hanping Feng, Stephen W. Hoag · 2017 · Pharmaceutical Research
11. Submicron Aggregation of Chemically Denatured Monoclonal Antibody
    Jacob B. Rowe, Rhiannon P. Flynn, Harrison R. Wooten, Hailey A. Noufer, Rachel A. Cancel, Jifeng Zhang, J. Anand Subramony, Sergei Pechenov, Ying Wang · 2018 · Molecular Pharmaceutics
12. Characterization of Protein Aggregation Using Hydrogel-Encapsulated nIR Fluorescent Nanoparticle Sensors
    Daniel P. Salem, Xun Gong, Heejin Lee, Alicia Zeng, Gang Xue, Jeff Schacherl, Scott Gibson, Michael S. Strano · 2020 · ACS Sensors
13. Therapeutic peptides for the treatment of cystic fibrosis: Challenges and perspectives
    Valentina Sala, Sophie Cnudde, Alessandra Murabito, Alberto Massarotti, Emilio Hirsch, Alessandra Ghigo · 2021 · European Journal of Medicinal Chemistry
14. Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies
    Shrenik C. Mehta, Heather Flores, Benjamin T. Walters, Alavattam Sreedhara · 2021 · Pharmaceutical Research
15. Direct Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies
    David C. Luther, Harini Nagaraj, Ritabrita Goswami, Yağız Anıl Çiçek, Taewon Jeon, Sanjana Gopalakrishnan, Vincent M. Rotello · 2022 · Pharmaceutical Research
16. Investigation of the pH-dependent aggregation mechanisms of GCSF using low resolution protein characterization techniques and advanced molecular dynamics simulations
    Suk Kyu Ko, Carolin Berner, Alina Kulakova, Markus Schneider, Iris Antes, Gerhard Winter, Pernille Harris, Günther Herbert Johannes Peters · 2022 · Computational and Structural Biotechnology Journal
17. Factors to Govern Soluble and Insoluble Aggregate-formation in Monoclonal Antibodies
    Jun Fukuda, Takafumi Iwura, Shigehiro Yanagihara, Kenji Kano · 2015 · Analytical Sciences
18. Computational study of aggregation mechanism in human lysozyme[D67H]
    Dharmeshkumar J. Patel, Serdar Kuyucak B · 2017 · PLoS ONE
19. Microparticles Locally Deliver Active Interleukin‐1 Receptor Antagonist In Vivo
    Anna E. B. Clements, Emily R. Groves, Connie S. Chamberlain, Ray Vanderby, William L. Murphy · 2018 · Advanced Healthcare Materials
20. Combination of circular dichroism spectroscopy and size-exclusion chromatography coupled with HDX-MS for studying global conformational structures of peptides in solution
    Nicole M. Schiavone, Gregory F. Pirrone, Erik D. Guetschow, Ian K. Mangion, Alexey A. Makarov · 2018 · Talanta
21. Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry
    Masanori Noda, Kentaro Ishii, Mika Yamauchi, Hiroaki Oyama, Takashi Tadokoro, Katsumi Maenaka, Tetsuo Torisu, Susumu Uchiyama · 2019 · Journal of Pharmaceutical Sciences
22. Determination of interactions between antibody biotherapeutics and copper by size exclusion chromatography (SEC) coupled with inductively coupled plasma mass spectrometry (ICP/MS)
    Yanxin Luo, Michael Ronk, Marisa K. Joubert, David J. Semin, Yasser Nashed-Samuel · 2019 · Analytica Chimica Acta
23. Characterization and Control of Dynamic Rearrangement in a Self-Assembled Antibody Carrier
    Anshul Dhankher, Manuel E. Hernandez, Hannah C. Howard, Julie A. Champion · 2020 · Biomacromolecules
24. Electron microscopy-based semi-automated characterization of aggregation in monoclonal antibody products
    Mohit Kumar, Apoorv Pant, Rohit Bansal, Ashutosh Pandey, James Gomes, Kedar Khare, Anurag Singh Rathore, Manidipa Banerjee · 2020 · Computational and Structural Biotechnology Journal
25. Optimized peptide nanofibrils as efficient transduction enhancers for in vitro and ex vivo gene transfer
    Lena Rauch‐Wirth, Alexander Renner, Kübra Kaygisiz, Tatjana Weil, Laura Zimmermann, Armando Rodríguez, Desirée Schütz, Sebastian Wiese, Ludger Ständker, Tanja Weil et al. · 2023 · Frontiers in Immunology
26. Protein Association in Solution: Statistical Mechanical Modeling
    Vojko Vlachy, Yu. V. Kalyuzhnyi, Barbara Hribar-Lee, Ken A. Dill · 2023 · Biomolecules
27. Mapping the mAb Aggregation Propensity Using Self-Interaction Chromatography as a Screening Tool
    Sarah Hedberg, Dong‐Kyu Lee, Yash Mishra, Jonathan M. Haigh, Daryl R. Williams · 2018 · Analytical Chemistry
28. Biophysical characterization and molecular simulation of electrostatically driven self‐association of a single‐chain antibody
    Christopher J. O'Brien, Cesar Calero‐Rubio, Vladimir I. Razinkov, Anne Skaja Robinson, Christopher J. Roberts · 2018 · Protein Science
29. Complex injectables
    Abhijeet P. Pandey, Debjani Singh, Namdev L. Dhas, Akhilesh Kumar Tewari, Kamla Pathak, Vivekanand Kisan Chatap, Kamal Singh Rathore, Srinivas Mutalik · 2020 · Elsevier eBooks
30. A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers
    James T. Heads, Sebastian Kelm, Kerry L. Tyson, Alastair D. G. Lawson · 2022 · mAbs
31. Investigation of quaternary structure of aggregating 3-ketosteroid dehydrogenase from Sterolibacterium denitrificans: In the pursuit of consensus of various biophysical techniques
    Kamila Sofińska, Agnieszka M. Wojtkiewicz, Patrycja Wójcik, Olga Zastawny, Maciej W. Guzik, Agnieszka Winiarska, Piotr Waligórski, Michał Cieśla, Jakub Barbasz, Maciej Szaleniec · 2019 · Biochimica et Biophysica Acta (BBA) - General Subjects
32. Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2
    Yue Hu, Ronald T. Toth, Sangeeta B. Joshi, Reza Esfandiary, Charles Russell Middaugh, David B. Volkin, David D. Weis · 2019 · Journal of Pharmaceutical Sciences
33. Formulation Composition and Process Affect Counterion for CSP7 Peptide
    Sawittree Sahakijpijarn, Chaeho Moon, John J. Koleng, Robert O. Williams · 2019 · Pharmaceutics
34. Nonionic detergent micelle aggregates: An economical alternative to protein A chromatography
    Gunasekaran Dhandapani, Ellen J. Wachtel, Mordechai Sheves, Guy Patchornik · 2020 · New Biotechnology
35. Evaluation of etanercept degradation under oxidative stress and potential protective effects of various amino acids
    Jun Yeul Lim, Nam Ah Kim, Dae Gon Lim, Ki Hyun Kim, Shavron Hada, Seong Hoon Jeong · 2015 · International Journal of Pharmaceutics
36. Deciphering Copper Homeostasis and Cuproptosis: Biological Mechanisms, Disease Connections, and Cutting-Edge Copper-Based Nanomedicine
    Shu-Xin Zhang, Lei Li, Lu-jin Wang, Nan-Nan Chen, Fan Leng, Hua-Zhen Xu, Tong‐Fei Li · 2026 · Molecular Pharmaceutics
37. Application of a High Throughput and Automated Workflow to Therapeutic Protein Formulation Development
    Cindy D. Ren, Wei Qi, Emily A. Wyatt, Jeffrey Yeary, Kimberly Westland, Michael Berke, Nitin Rathore · 2020 · Journal of Pharmaceutical Sciences
38. Toward Isolation of Palytoxins: Liquid Chromatography Coupled to Low- or High-Resolution Mass Spectrometry for the Study on the Impact of Drying Techniques, Solvents and Materials
    Antonia Mazzeo, Michela Varra, Luciana Tartaglione, Patrizia Ciminiello, Zita Zendong, Philipp Heß, Carmela Dell’Aversano · 2021 · Toxins
39. Role of ionic liquids on stabilization of therapeutic proteins and model proteins
    Maya Guncheva · 2022 · The Protein Journal
40. Stability and Biosimilarity Assessment of Bevacizumab Monoclonal Antibody; Orthogonal Testing Protocol Coupled With Peptide Mapping–Principal Component Analysis
    Sara Hesham Abdelghaffar, Maha Abdel Monem Hegazy, Basma Mohamed Eltanany · 2023 · Journal of AOAC International
41. Probing Conformational Diversity of Fc Domains in Aggregation-Prone Monoclonal Antibodies
    Subhabrata Majumder, Michael T. Jones, Michael Kimmel, Arun Alphonse Ignatius · 2018 · Pharmaceutical Research
42. Challenges with osmolytes as inhibitors of protein aggregation: Can nucleic acid aptamers provide an answer?
    Kinjal A. Patel, Ratnika Sethi, Anita R. Dhara, Ipsita Roy · 2016 · International Journal of Biological Macromolecules
43. Engineered polymeric excipients for enhancing the stability of protein biologics: Poly(N-isopropylacrylamide)-poly(ethylene glycol) (PNIPAM-PEG) block copolymers
    Taesuk Jun, Sung-Ho Shin, You‐Yeon Won · 2024 · International Journal of Pharmaceutics
44. Feasibility of electrospraying fully aqueous bovine serum albumin solutions
    Maarten Batens, Loís Dewaele, Jan Massant, Bianca Teodorescu, Christian Clasen, Guy Van den Mooter · 2019 · European Journal of Pharmaceutics and Biopharmaceutics
45. Recombinant antibodies aggregation and overcoming strategies in CHO cells
    Tingting Xu, Jihong Zhang, Tianyun Wang, Xiaoyin Wang · 2022 · Applied Microbiology and Biotechnology
46. Conformational Changes and Drivers of Monoclonal Antibody Liquid-Liquid Phase Separation
    Nicholas R. Larson, Yangjie Wei, Thayana A. Cruz, Reza Esfandiary, Cavan K. Kalonia, Marcus Laird Forrest, Charles Russell Middaugh · 2022 · Journal of Pharmaceutical Sciences
47. Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry
    Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong‐Feng Xu · 2024 · mAbs
48. Improving the stability of insulin through effective chemical modifications: A Comprehensive review
    Reyhane Kamelnia, Mahmood Ahmadi‐hamedani, Majid Darroudi, Elahe Kamelnia · 2024 · International Journal of Pharmaceutics
49. Predictive Model Building for Aggregation Kinetics Based on Molecular Dynamics Simulations of an Antibody Fragment
    Yuhan Wang, Hywel D. Williams, Duygu Dikicioǧlu, Paul Anthony Dalby · 2024 · Molecular Pharmaceutics
50. Impact of Sugar Molecular Weight on the Miscibility and Stability of Lyophilized and Spray-Dried Protein Formulations
    Hanh Thuy Nguyen, Mennatallah A. Mohamed, Jing Ling, Yong Du, Kevin Kjoller, Yongchao Su, Lynne S. Taylor · 2025 · Molecular Pharmaceutics
51. Advancing forced degradation studies: Design of experiments for enhanced structure-function relationship analysis in biotherapeutics
    Klaus Kronsbein, Verena Nold, Armin Böhrer, Beate Presser, Tanja Gaissmaier, Katharina Schindowski, Boris Mizaikoff, Florian Krattenmacher · 2025 · European Journal of Pharmaceutics and Biopharmaceutics
52. AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing
    Y. Allen Tao, Holt A. Sakai, Allen Yujie Jiang, Nicholas Andrew Krasnow, Vasilii Vaganov, Brian H. Shim, Zachary Barsdale, Smriti Pandey, Nouraiz Ahmed, Man Na et al. · 2026 · Nature Biotechnology
53. Polyrotaxane-Based Supramolecular Material for Improvement of Pharmaceutical Properties of Protein Drugs
    Tetsuya Kogo, Kosei Utatsu, Toru Taharabaru, Risako Onodera, Keiichi Motoyama, Taishi Higashi · 2022 · Journal of Pharmaceutical Sciences
54. Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers
    Kyung Hwa Chang, Bong Joo Park, Ki Chang Nam · 2023 · AAPS PharmSciTech
55. Concentration-Dependent Diffusion of Monoclonal Antibodies: Underlying Mechanisms of Anomalous Diffusion
    Gaurav Kumar, Arezoo M. Ardekani · 2024 · Molecular Pharmaceutics
56. Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity
    Arisa Yamashita, Yuri Hiraki, Tetsuo Yamazaki · 2017 · Biochemical and Biophysical Research Communications
57. Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation
    Kevin P. Kent, Chad E. Schroeder, Chandana Sharma · 2017 · Journal of Pharmaceutical Analysis
58. Suppression of Aggregation of Therapeutic Monoclonal Antibodies during Storage by Removal of Aggregation Precursors Using a Specific Adsorbent of Non-Native IgG Conformers
    Yukako Senga, Shinya Honda · 2018 · Bioconjugate Chemistry
59. Rapid and Simple Analysis of the Human Pepsin Secondary Structure Using a Portable Raman Spectrometer
    Tong‐Jiang Li, Bao‐Ying Wen, Xiao‐Hui Ma, Wanting Huang, Jinzhun Wu, Xiu‐Mei Lin, Yue‐Jiao Zhang, Jian‐Feng Li · 2021 · Analytical Chemistry
60. Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association
    Lok Hin Lui, Christopher F. van der Walle, Steve Brocchini, Ajoy Velayudhan · 2022 · Antibodies
61. Biophysical Characterization of Binary Therapeutic Monoclonal Antibody Mixtures
    Dennis Krieg, Carolin Berner, Gerhard Winter, Hristo L. Svilenov · 2020 · Molecular Pharmaceutics
62. Physics of Protein Aggregation in Normal and Accelerated Brain Aging
    Alberto Javier Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady J. Williamson, Kora T Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanović, Fredric P. Manfredsson · 2025 · BioEssays
63. Impact of Urea on Monoclonal Antibodies: Multiple Destabilization and Aggregation Effects for Therapeutic Immunoglobulin G Proteins
    Jiyoung Yang, Oliver Burkert, Boris Mizaikoff, Jens Smiatek · 2024 · ACS Omega
64. Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons
    James A. Madsen, Yan Yin, Jing Qiao, Vanessa Leah Gill, Kutralanathan Renganathan, Wing-Yee Fu, Stephen Smith, James Anderson · 2016 · Analytical Chemistry
65. AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG
    Yukako Senga, Hiroshi Imamura, Takamitsu Miyafusa, Hideki Watanabe, Shinya Honda · 2017 · Scientific Reports
66. Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity
    Mitsuaki Takeuchi, Masayuki Okamoto, Ryuji Okamoto, Hiroshi Kinoshita, Yu Yamaguchi, Nobuhide Watanabe · 2018 · Peptides
67. Selective Stabilization and Destabilization of Protein Domains in Tissue-Type Plasminogen Activator Using Formulation Excipients
    Mathew J. Robinson, Paul Matejtschuk, Colin Longstaff, Paul Anthony Dalby · 2018 · Molecular Pharmaceutics
68. Size-based Degradation of Therapeutic Proteins - Mechanisms, Modelling and Control
    Rohit Bansal, Saurabh Kumar Jha, Niraj Kumar Jha · 2021 · BioMolecular Concepts
69. Application of Tunable Resistive Pulse Sensing for the Quantification of Submicron Particles in Pharmaceutical Monoclonal Antibody Preparations
    Andreas Stelzl, Stefan C. Schneid, Gerhard Winter · 2021 · Journal of Pharmaceutical Sciences
70. Succinate Buffer in Biologics Products: Real-world Formulation Considerations, Processing Risks and Mitigation Strategies
    Anvay Ukidve, Kelvin B. Rembert, Ragaleena Vanipenta, Patrick Dorion, Pierre Lafarguette, T. J. McCoy, Atul Saluja, Raj Suryanarayanan, Sanket Patke · 2022 · Journal of Pharmaceutical Sciences
71. Predicting Experimental B22 Values and the Effects of Histidine Charge States for Monoclonal Antibodies Using Coarse-Grained Molecular Simulations
    Hassan Shahfar, Christopher J. O’Brien, Ivan L. Budyak, Christopher J. Roberts · 2022 · Molecular Pharmaceutics
72. High-Throughput Counting and Sizing of Therapeutic Protein Aggregates in the Nanometer Size Range by Nano-Flow Cytometry.
    Kaimin Gao, Hong-Xia Lian, Cheng-Feng Xue, Jing Zhou, Xiao-Mei Yan · 2022 · Analytical Chemistry
73. Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways
    Diana Gomes, Rebecca K. Kalman, Rebecca K. Pagels, Miguel Ângelo Rodrigues, Christopher J. Roberts · 2018 · Protein Science
74. On the Reproducibility of Early-Stage Thermally Induced and Contact-Stir-Induced Protein Aggregation
    Curtis W. Jarand, Wayne F. Reed · 2018 · The Journal of Physical Chemistry B
75. Stability of intravenous antibody dilutions in clinical use: Differences across patient populations with varying body weights
    Dongze Xu, Sha Guo, Qi Zhou, Pengfei He, Xiang Guo, Hanhan Li, Zhenhao Zhou, Xueyan Hu, Cui Wang, Chuanfei Yu et al. · 2025 · International Journal of Pharmaceutics
76. Chemical synthesis uncovers the significant impact of natural glycosylation on islet amyloid polypeptide aggregation
    Yaohao Li, Wenqiang Liu, Ruihan Wang, Dan Liu, Xin Li, Chuang Zhang, Jinyuan Gong, Zerun Song, Yajing Zhang, Zhongping Tan · 2025 · Science Advances
77. The Process of L-Asparaginase Encapsulation by Poly (Lactic-Co-Glycolic Acid) and Methoxy Poly (Ethylene Glycol): A Molecular Dynamics Simulation Study
    Sama Jawad Al-Zuwaini, Faramarz Mehrnejad, Zahra Lotfi-Sousefi, Ali Hossein Rezayan, Mohammad Barshan Tashnizi · 2022 · Materials Today Communications
78. Enhancing affinity purification of monoclonal antibodies from human serum for subsequent CZE-MS analysis
    Tessa Reinert, Pascal Houzé, Yannis‐Nicolas François, Rabah Gahoual · 2024 · Journal of Chromatography B
79. Highly variable aggregation and glycosylation profiles and their roles in immunogenicity to protein-based therapeutics
    Sina Sarsarshahi, Sanghati Bhattacharya, Zeb Ralph Zacharias, Eman S. Kamel, Jon C. D. Houtman, M. Reza Nejadnik · 2025 · Journal of Pharmaceutical Sciences
80. How Full-Length FVIII Benefits from Its Heterogeneity – Insights into the Role of the B-Domain
    Julia Anzengruber, Martin Feichtinger, Philipp Bärnthaler, Norbert Haider, Josenato Ilas, Nina Pruckner, Karima Benamara, Friedrich Scheiflinger, Birgit Maria Reipert, Mantas Mališauskas · 2019 · Pharmaceutical Research
81. Study of the interaction between a novel, protein-stabilizing dipeptide and Interferon-alpha-2a by construction of a Markov state model from molecular dynamics simulations
    Andreas Tosstorff, Günther Herbert Johannes Peters, Gerhard Winter · 2020 · European Journal of Pharmaceutics and Biopharmaceutics
82. Design of a Novel Fab‐Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use
    Chunyu Wang, Jiaxu Hong, Zhenlin Yang, Xujiao Zhou, Yuhan Yang, Yu Kong, Binfan Chen, Huifang Wu, Bin‐Zhi Qian, Dimiter Stanchev Dimitrov et al. · 2021 · Small Methods
83. Prediction of the Effect of pH on the Aggregation and Conditional Folding of Intrinsically Disordered Proteins with SolupHred and DispHred
    Valentín Iglesias, Carlos Pintado‐Grima, Jaime Santos, Marc Fornt‐Suñé, Salvador Ventura · 2022 · Methods in molecular biology
84. Monocyclic phenolic compounds stabilize human insulin and suppress its amorphous aggregation: In vitro and in vivo study
    Sepideh Haghighi-Poodeh, Latifeh Navidpour, Parichehreh Yaghmaei, Azadeh Ebrahim‐Habibi · 2019 · Biochemical and Biophysical Research Communications
85. Chapter 14: Practical Considerations in High Concentration Formulation Development for Monoclonal Antibody Drug Products
    Qingyan Hu, Bowen Jiang, Dingjiang Liu, Xiaolin Charlie Tang, Thomas J. Daly, Mohammed Shameem · 2020 · AAPS advances in the pharmaceutical sciences series
86. Investigating the Role of Surface Hydrophobicity in Protein Aggregation
    Elizabeth Zecca · 2017 · OpenCommons at University of Connecticut (University of Connecticut)
87. Challenges for design of aggregation-resistant variants of granulocyte colony-stimulating factor
    Gulsum Meric, Subhashchandra Naik, Alan K. Hunter, Anne Skaja Robinson, Christopher J. Roberts · 2021 · Biophysical Chemistry
88. Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding
    Alina Kulakova, Dillen Augustijn, Inas El Bialy, Lorenzo Gentiluomo, Maria Laura Greco, Stefan Hervø-Hansen, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl et al. · 2023 · Molecular Pharmaceutics
89. Multidomain Protein–Urea Interactions: Differences in Binding Behavior Lead to Different Destabilization Tendencies for Monoclonal Antibodies
    Jiyoung Yang, Oliver Burkert, Boris Mizaikoff, Jens Smiatek · 2024 · The Journal of Physical Chemistry B
90. Potential risk factors of protein aggregation in syringe handling during antibody drug dilution for intravenous administration
    Masakazu Fukuda, Shino Nagae, Toru Takarada, Satoshi Noda, Shin‐ya Morita, Masafumi Tanaka · 2025 · Journal of Pharmaceutical Sciences
91. From cell clones to recombinant protein product heterogeneity in Chinese hamster ovary cell systems
    Wang, Chong, Guo, Xiao, Wang, Wen, Li, Jia-Xin, Wang, Tian-Yun · 2025 · International Journal of Molecular Sciences
92. Positive response to surfactants on the interfacial behavior and aggregation stability of Fab fragments from yolk immunoglobulin
    Minquan Xia, Yanru Wang, Long Sheng, Zhaoxia Cai, Xin Gang Zhou · 2021 · International Journal of Biological Macromolecules
93. Stability Convergence in Antibody Coformulations
    Hongyu Zhang, Paul Anthony Dalby · 2022 · Molecular Pharmaceutics
94. Design of self-assembled glycopolymeric zwitterionic micelles as removable protein stabilizing agents
    Robin Rajan, Kazuaki Matsumura · 2023 · Nanoscale Advances
95. Predictive Nature of High-Throughput Assays in ADC Formulation Screening
    Brittney J. Mills, Malika P. Godamudunage, Siyuan Ren, Malabika Laha · 2023 · Journal of Pharmaceutical Sciences
96. Generation of mAb Variants with Less Attractive Self-Interaction but Preserved Target Binding by Well-Directed Mutation
    Martin Domnowski, Ken Lo Presti, Jonas Binder, Josef Reindl, Lucille Lehmann, Felix Kummer, Meike Wolber, Marion Satzger, Marco Dehling, Jan Jaehrling et al. · 2020 · Molecular Pharmaceutics
97. Anti-EGFR VHH Antibody under Thermal Stress Is Better Solubilized with a Lysine than with an Arginine SEP Tag
    Md. Golam Kibria, Akari Fukutani, Yoko Ogawa, Yoshihisa Hagihara, Yutaka Kuroda · 2021 · Biomolecules
98. Stability assessment of FDA‐approved ramucirumab monoclonal antibody; validated SE‐HPLC method for degradation pattern evaluation
    Sara Hesham Abdelghaffar, Maha Abdel Monem Hegazy, Basma Mohamed Eltanany · 2021 · Biomedical Chromatography
99. Investigation of the Impact of Saccharides on the Relative Activity of Trypsin and Catalase after Droplet and Spray Drying
    Johanna Dieplinger, Christina Möser, Gerhard König, Joana T. Pinto, Amrit Paudel · 2023 · Pharmaceutics
100. Preferential Binding of Cations Modulates Electrostatically Driven Protein Aggregation and Disaggregation
     Deepika Singla, Mily Bhattacharya · 2024 · The Journal of Physical Chemistry B