New Horizons in Acetogenic Conversion of One-Carbon Substrates and Biological Hydrogen Storage
Abstract
Strictly anaerobic, acetogenic (acetate-forming) bacteria are characterized by a reductive pathway in which two mol of CO 2 are reduced to one mol of acetyl coenzyme A (acetyl-CoA) and then further to acetate, ethanol, or butyrate. Therefore, they have come into focus for an alternative, CO 2 -based bioeconomy. Other one-carbon (C1) substrates, such as formic acid or methanol, are promising feedstocks for an alternative bioeconomy using acetogens as biocatalysts that have been somewhat overlooked. In addition, acetogens, such as Acetobacterium woodii and Thermoanaerobacter kivui, have a unique enzyme system capable of reducing CO 2 to formate with H 2 as reductant that is superior over any chemical catalyst for CO 2 -based hydrogen storage. Therefore, acetogens are also promising candidates in the hydrogen economy as potential catalysts for hydrogen storage or production.
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The H2-dependent carbon dioxide reductase (HDCR) was absent in all but one MAG (MAG2125).
“The H2-dependent carbon dioxide reductase (HDCR) [47–49] was absent in all but one MAG (MAG2125)”
From Reductive acetogenesis is a dominant process in the ruminant hindgut (2025) · cites this paper as [49]
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Acetone production with metabolically engineered strains of Acetobacterium woodii
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Lactose-inducible system for metabolic engineering of Clostridium ljungdahlii
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Reductive acetogenesis is a dominant process in the ruminant hindgut
Li, Q., Huo, J., Ni, G., Zhang, F., Zhang, S., Zhang, X., Wang, R., Jiao, J., Yu, Z., Pu, X., et al. (2025) · Microbiome · doi:10.1186/s40168-024-02018-1 · Cited by 22 · see citing works
- Authors
- Müller, V.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Müller, Volker
- ORCID
- Müller, Volker
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 37
- Issue
- 12
- Pages
- 1344-1354
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2955696126
- Cited by
- 135
- References
- 7
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 14 · 2023: 17 · 2022: 29 · 2021: 25 · 2020: 21 · 2019: 2
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
- Keywords
- acetogenic bacteria, CO2 reduction, Acetobacterium woodii, Thermoanaerobacter kivui, formic acid, methanol, acetyl-CoA, hydrogen economy, biocatalysis
- MeSH terms
- Acetates, Carbon, Carbon Dioxide, Hydrogen, Acetobacterium
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