Oculomotor prediction: A window into the psychotic mind
Open accessAbstract
Psychosis - an impaired contact with reality - is a hallmark of schizophrenia. Many psychotic symptoms are associated with disruptions in agency - the sense that 'I' cause my actions. A failure to predict sensory consequences of one's own actions may underlie agency disturbances. Such predictions rely on corollary discharge (CD) signals, 'copies' of movement commands sent to sensory regions prior to action execution. Here, we make a case that the oculomotor system is a promising model for understanding CD in psychosis, building on advances in our understanding of the behavioral and neurophysiological correlates of CD associated with eye movements. In this opinion article, we provide an overview of recent evidence for disturbed oculomotor CD in schizophrenia, potentially linking bizarre and disturbing psychotic experiences with basic physiological processes.
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Disruption of corollary discharge as a form of predictive signaling may be more broadly relevant for both hallucinations and delusions, which both entail aberrant inferences about agency and the intentions of others.
“In this case, disruption of corollary discharge as a form of predictive signaling may be more broadly relevant for both hallucinations and delusions, which both entail aberrant inferences about agency and the intentions of others.”
From The Predictive Coding Account of Psychosis (2018) · cites this paper as [86]
In “Oculomotor probes of agency disturbances in psychosis” (page unavailable), the paper links disrupted corollary discharge to altered agency in both hallucinations and delusions. It describes external attribution of one's own thoughts and actions, but does not address aberrant inferences about the intentions of others. (LLM, conf=0.86)
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References 117 · Cited by 66
Research works printed but not linked: 1
- [111]Newsome WT 1988 Relation of cortical areas MT and MST to pursuit eye movements. II. Differentiation of retinal from extraretinal inputs J Neurophysiol 60 604 620 3171644
- Authors
- Thakkar, K. N., Diwadkar, V. A., & Rolfs, M.
- Affiliations
- Michigan State University (US)
- Wayne State University (US)
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Thakkar, Katharine N.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 21
- Issue
- 5
- Pages
- 344-356
- ISSN
- 1364-6613 (ISSN-L)
- PMC
- PMC5401650
- OpenAlex
- W2593348554
- Cited by
- 66
- References
- 117
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 11 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 4
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH111177, MH059299)
- Deutsche Forschungsgemeinschaft (RO 3579/2-1, RO 3579/3-1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- corollary discharge, schizophrenia, psychosis, agency, eye movements, sensory prediction
- MeSH terms
- Eye Movements, Humans, Movement, Psychotic Disorders, Schizophrenia, Sensation
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