Bioactive compounds from marine macroalgae and their hypoglycemic benefits
Open accessAbstract
Diabetes mellitus is a group of chronic metabolic disorders characterized by hyperglycemia due to defects in insulin action and/or secretion. It is a worldwide problem which has led to illness and premature mortality for many people, and the number of diabetes cases has been rising sharply. Unluckily, many conventional antidiabetic agents either show limited efficacy or serious mechanism-based side effects. Marine macroalgae possess tremendous nutritional value and have been well-known to cure and prevent diabetes. An increased interest in various bioactive natural products from marine macroalgae, as a potential source of effective antidiabetic agents, has been observed in recent years. The effects of macroalgae may delay the development of diabetes and alter the metabolic abnormalities through various mechanisms of actions. This review provides an overview of marine macroalgae used to prevent and manage diabetes and explores the hypoglycemic properties of macroalgae-derived bioactive compounds such as polyphenol, bromophenols, sulfated polysaccharides, fucoidan, fucosterol, phlorotannins, carotenoid pigments and fucoxanthin with their probable mechanisms behind hypoglycemic activity.
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Ethanol extracts of many algae can change the gut microbiota.
“Moreover, ethanol extracts of many algae can change the gut microbiota [6,14].”
From Regulatory Efficacy of the Polyunsaturated Fatty Acids from Microalgae Spirulina platensis on Lipid Metabolism and Gut Microbiota in High-Fat Diet Rats (2018) · cites this paper as [6]
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References 139 · Cited by 235
Research works printed but not linked: 3
- Atlas, I. D. (2009). The global burden. International Diabetes Federation. 4th Edition Brussels, 21-27.
- Renner, S., & Ricklefs, E. (1995). Dioecy and its correlates in the flowering plants. American Journal of Botany , 82 , 596-606.
- Zhao, C., Wu, Y. J., Yang, C. F., Liu, B., & Huang, Y, F. (2015). Hypotensive, hypoglycemic and hypolipidemic effects of bioactive compounds from microalgae and marine microorganisms. International Journal of Food Science and Technology , 50 , 1705-1717.
- Authors
- Zhao, C., Yang, C., Liu, B., Lin, L., Sarker, S. D., Nahar, L., Yu, H., Cao, H., & Xiao, J.
- Affiliations
- Quanzhou Normal University (CN)
- Fujian Agriculture and Forestry University (CN)
- Liverpool John Moores University (GB)
- University of Macau (MO)
- Corresponding author
- Xiao, Jianbo
- Venue
- Trends in Food Science & Technology
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 72
- Pages
- 1-12
- ISSN
- 0924-2244 (ISSN-L)
- OpenAlex
- W2773946960
- Cited by
- 235
- References
- 139
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 29 · 2023: 28 · 2022: 38 · 2021: 33 · 2020: 26 · 2019: 35 · 2018: 18 · 2017: 1 · 2012: 1
- FWCI
- 25.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 310 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Trends in Food Science & Technology (acceptedVersion)
- Liverpool John Moores University (submittedVersion)
- Funders
- Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae (2017FZSK05)
- National Science Foundation (2016J06009)
- Marine High-tech Industrial Development Project (MIN2014-17)
- FAFU (KXb16011A, 612014043)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- seaweed, hypoglycemic activity, diabetes mellitus, antidiabetic drugs, bioactive compounds, polyphenols, bromophenols, sulfated polysaccharides, fucoidan, fucosterol, phlorotannins, carotenoids, fucoxanthin, hyperglycemia, insulin resistance
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