Macroalgal-derived protein hydrolysates and bioactive peptides: Enzymatic release and potential health enhancing properties
Abstract
Macroalgae are a natural source of valuable compounds for different applications. Despite the high protein content (up to 47%) and complete essential amino acid profile in some species, their protein fraction is still relatively underexplored. Besides the potential as alternative protein sources, macroalgae can also provide bioactive peptides and other proteinaceous compounds with biological value.In this review, data associated with macroalgal nitrogenous components, particularly peptides and protein hydrolysates, are presented and discussed, especially regarding their potential health properties and methodologies employed to obtain and isolate them.Obtaining these compounds and assessing their biological activities involves a combination of preparation and analytical steps (e.g. isolation, purification, detection and quantification). Hydrolysis of macroalgal proteins using different proteinases generates multiple peptides with a broad range of biological activities. Further research and innovation will allow the development of more efficient production processes and will improve the range of applications. Current scientific evidences regarding the potential health benefits of macroalgae-derived proteinaceous compounds highlight the need of additional investments to effectively transfer promising findings into market driven opportunities.
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Microalgae contain 20-60% protein and macroalgae contain 1.3-47% protein of dry weight.
“Algae are a rich source of protein, with microalgae containing 20–60% and macroalgae (or seaweed) 1.3–47% of dry weight [20,21].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [21]
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References 116 · Cited by 81
- Authors
- Pimentel, F. B., Alves, R. C., Harnedy, P. A., FitzGerald, R. J., & Oliveira, M. B. P. P.
- Affiliations
- Universidade do Porto (PT)
- University of Limerick (IE)
- Corresponding author
- Alves, Rita C.
- Venue
- Trends in Food Science & Technology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 93
- Pages
- 106-124
- ISSN
- 0924-2244 (ISSN-L)
- OpenAlex
- W2972248217
- Cited by
- 81
- References
- 116
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 15 · 2023: 11 · 2022: 10 · 2021: 15 · 2020: 8
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Food Science & Technology (publishedVersion)
- Funders
- Ministério da Ciência, Tecnologia e Ensino Superior
- Fundação para a Ciência e a Tecnologia (UID/QUI/50006/2019, SFRH/BD/109042/2015)
- Marine Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Industry and Aquatic Biology
- Keywords
- seaweed, protein hydrolysates, bioactive peptides, enzymatic hydrolysis, proteolytic enzymes, alternative protein sources, health benefits, peptide purification, nitrogen compounds, functional food ingredients
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