Evolution of the cancer genome
Open accessAbstract
Human tumors result from an evolutionary process operating on somatic cells within tissues, whereby natural selection operates on the phenotypic variability generated by the accumulation of genetic, genomic and epigenetic alterations. This somatic evolution leads to adaptations such as increased proliferative, angiogenic, and invasive phenotypes. In this review we outline how cancer genomes are beginning to be investigated from an evolutionary perspective. We describe recent progress in the cataloging of somatic genetic and genomic alterations, and investigate the contributions of germline as well as epigenetic factors to cancer genome evolution. Finally, we outline the challenges facing researchers who investigate the processes driving the evolution of the cancer genome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several recent studies have shown a similar spectrum of genetic alterations to those observed here during the somatic evolution of cancers in patients undergoing chemotherapy or treated with specific inhibitors.
“Indeed, several recent studies have shown a similar spectrum of genetic alterations to those observed here during the somatic evolution of cancers in patients undergoing chemotherapy (Podlaha et al., 2012; Landau et al., 2013) or treated with specific inhibitors (Ding et al., 2012) to those observed here.”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Podlaha et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 103 · Cited by 188
- Authors
- Podlaha, O., Riester, M., De, S., & Michor, F.
- Affiliations
- Harvard University (US)
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 28
- Issue
- 4
- Pages
- 155-163
- ISSN
- 0168-9525 (ISSN-L)
- PMC
- PMC3711268
- OpenAlex
- W2067507447
- Cited by
- 188
- References
- 103
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 15 · 2015: 19 · 2014: 22 · 2013: 16 · 2012: 5
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (U54CA143798)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- cancer genome evolution, somatic evolution, tumor evolution, somatic mutations, somatic copy number alterations, epigenetic modifications, germline predisposition, tumor heterogeneity, tumor microenvironment, tumor invasion, angiogenesis, tumor cell proliferation
- MeSH terms
- Animals, Humans, Neoplasms, Genome, Disease Progression, Evolution, Molecular, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
