Alternative pre-mRNA splicing in neurons: growing up and extending its reach
Open accessAbstract
Alternative pre-mRNA splicing determines the protein output of most neuronally expressed genes. Many examples have been described of protein function being modulated by coding changes in different mRNA isoforms. Several recent studies demonstrate that, through the coupling of splicing to other processes of mRNA metabolism, alternative splicing can also act as an on/off switch for gene expression. Other regulated splicing events may determine how an mRNA is utilized in its later cytoplasmic life by changing its localization or translation. These studies make clear that the multiple steps of post-transcriptional gene regulation are strongly linked. Together, these regulatory process play key roles in all aspects of the cell biology of neurons, from their initial differentiation, to their choice of connections, and finally to their function with mature circuits.
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The mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function.
“the mammalian nervous system makes extensive use of splicing regulation to generate specialized protein isoforms that affect all aspects of neuronal development and function1–4.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [2]
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References 100 · Cited by 115
- Authors
- Zheng, S., & Black, D. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Black, Douglas L.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 29
- Issue
- 8
- Pages
- 442-448
- ISSN
- 0168-9525 (ISSN-L)
- PMC
- PMC3959871
- OpenAlex
- W1968849815
- Cited by
- 115
- References
- 100
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 1 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 11 · 2017: 9 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 3
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Mental Health (K99MH096807)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alternative splicing, neurons, post-transcriptional regulation, mRNA isoforms, mRNA localization, translational regulation, neuronal differentiation, neuronal connectivity, gene expression regulation
- MeSH terms
- Animals, Gene Expression Regulation, Neurons, RNA, Messenger, Alternative Splicing, Codon, Nonsense
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