The DOI matches its Crossref record; 198 of the 198 references it cites were found in a registry or an index.
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Open accessAbstract
Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important biochemical, cellular, and developmental activities is steadily growing. However, it is increasingly clear that lncRNA repertoires are subject to weak functional constraint and rapid turnover during vertebrate evolution. Here we discuss some of the factors that may explain this apparent paradox, including relaxed constraint on sequence to maintain lncRNA structure/function, extensive redundancy in the regulatory circuits in which lncRNAs act, as well as adaptive and non-adaptive forces such as genetic drift. We explore the molecular mechanisms promoting the birth and rapid evolution of lncRNA genes with an emphasis on the influence of bidirectional transcription and transposable elements, two pervasive features of vertebrate genomes. Together these properties reveal a remarkably dynamic and malleable noncoding transcriptome, which may represent an important source of robustness and evolvability.
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Regulatory activities of transposable elements: from conflicts to benefits
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Metadata
- Authors
- Kapusta, A., & Feschotte, C.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 30
- Issue
- 10
- Pages
- 439-452
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2008243402
- Cited by
- 295
- References
- 198
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
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