G-Quadruplexes in DNA Replication: A Problem or a Necessity?
Abstract
DNA replication is a highly regulated process that ensures the correct duplication of the genome at each cell cycle. A precise cell type-specific temporal program controls the duplication of complex vertebrate genomes in an orderly manner. This program is based on the regulation of both replication origin firing and replication fork progression. G-quadruplexes (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently emerged as key controllers of genome duplication. Here we discuss the various means by which G4s affect this fundamental cellular process.
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Further reports demonstrated that G4s cause replication-dependent DNA-damage or change the overall chromatin structure.
“Further reports demonstrated that G4s cause replication-dependent DNA-damage or change the overall chromatin structure (66,67).”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [67]
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References 61 · Cited by 149
- Authors
- Valton, A.-L., & Prioleau, M.-N.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Prioleau, Marie-Noëlle
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 32
- Issue
- 11
- Pages
- 697-706
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2523122226
- Cited by
- 149
- References
- 61
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 14 · 2022: 13 · 2021: 24 · 2020: 16 · 2019: 23 · 2018: 12 · 2017: 15
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-15-CE12-0004)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- G-quadruplex, DNA replication, replication origin firing, replication fork progression, whole-genome duplication, DNA secondary structure, cell cycle regulation, vertebrate genomes
- MeSH terms
- Cell Cycle, DNA, DNA Replication, Nucleic Acid Conformation, Genome, Replication Origin, Cell Lineage, Base Pairing, G-Quadruplexes
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