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Germline Variants That Affect Tumor Progression
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“Beyond mutagenesis, germline genetic variation shapes tissue-specific mutational fitness, with clones bearing a selective advantage attaining dominance at the expense of others6,7.”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [7]
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“Germline genetic variation is known to influence both mutagenesis and clonal fitness1–7.”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [7]
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Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114
Next-generation characterization of the Cancer Cell Line Encyclopedia
Ghandi, M., Huang, F. W., Jané-Valbuena, J., Kryukov, G. V., Lo, C. C., McDonald, E. R., Barretina, J., Gelfand, E. T., Bielski, C. M., Li, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1186-3 · Cited by 3,394
Pan-cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064
Germline Mutations in Predisposition Genes in Pediatric Cancer
Zhang, J., Walsh, M. F., Wu, G., Edmonson, M. N., Gruber, T. A., Easton, J., Hedges, D., Ma, X., Zhou, X., Yergeau, D. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1508054 · Cited by 1,345
Park, J.-H., Gail, M. H., Weinberg, C. R., Carroll, R. J., Chung, C. C., Wang, Z., Chanock, S. J., Fraumeni, J. F., & Chatterjee, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114759108 · Cited by 280
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Cited by
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Liu, J., Tran, D., Xue, L., Wiley, B. J., Vlasschaert, C., Watson, C. J., MacGregor, H. A. J., Zong, X., Chan, I. C. C., Das, I., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02250-x · Cited by 33
Metadata
- Authors
- Chatrath, A., Ratan, A., & Dutta, A.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 37
- Issue
- 5
- Pages
- 433-443
- ISSN
- 0168-9525
- PMC
- PMC8043969
- Cited by
- 50
- References
- 5
- Language
- en
- Funders
- National Institutes of Health
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