The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
FIRRM and FIGNL1: partners in the regulation of homologous recombination
Open accessAbstract
DNA repair through homologous recombination (HR) is of vital importance for maintaining genome stability and preventing tumorigenesis. RAD51 is the core component of HR, catalyzing the strand invasion and homology search. Here, we highlight recent findings on FIRRM and FIGNL1 as regulators of the dynamics of RAD51.
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Out of the 40,459 genome maintenance pairs, 1,141 are reported in both BioGrid and IntAct.
“This analysis revealed that out of the 40,459 pairs in the GM set, 1,141 are reported in both BioGrid and IntAct59.”
From Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions (2025) · cites this paper as [59]
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Cites
FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination
Fernandes, J. B., Duhamel, M., Seguéla-Arnaud, M., Froger, N., Girard, C., Choinard, S., Solier, V., De Winne, N., De Jaeger, G., Gevaert, K., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007317 · Cited by 116
Flagged first, then by citations
Research works printed but not linked: 14
- Krejci, 2012, Homologous recombination and its regulation, Nucleic Acids Res., 40, 5795, 10.1093/nar/gks270 · DOI
- Adolph, 2021, RADX controls RAD51 filament dynamics to regulate replication fork stability, Mol. Cell, 81, 1074, 10.1016/j.molcel.2020.12.036 · DOI
- Yuan, 2013, FIGNL1-containing protein complex is required for efficient homologous recombination repair, Proc. Natl. Acad. Sci. U. S. A., 110, 10640, 10.1073/pnas.1220662110 · DOI
- Matsuzaki, 2019, Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase, Nat. Commun., 10, 1407, 10.1038/s41467-019-09190-1 · DOI
- Hu, 2017, Meiotic chromosome association 1 interacts with TOP3α and regulates meiotic recombination in rice, Plant Cell, 29, 1697, 10.1105/tpc.17.00241 · DOI
- Urzúa-Traslaviña, 2021, Improving gene function predictions using independent transcriptional components, Nat. Commun., 12, 1464, 10.1038/s41467-021-21671-w · DOI
- Zhou, 2023, C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair, Cell Rep., 42, 10.1016/j.celrep.2023.112907 · DOI
- Mazouzi, 2023, FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks, Sci. Adv., 9, 10.1126/sciadv.adf4409 · DOI
- Pinedo-Carpio, 2023, FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair, Sci. Adv., 9, 10.1126/sciadv.adf4082 · DOI
- Tischler, 2024, FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress, Nat. Commun., 15, 866, 10.1038/s41467-024-45139-9 · DOI
- Stok, 2023, FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics, Cell Rep., 42, 10.1016/j.celrep.2023.112668 · DOI
- Zhang, 2023, The FLIP–FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart, Nucleic Acids Res., 51, 8606, 10.1093/nar/gkad596 · DOI
- Ito, 2023, FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination, Nat. Commun., 14, 6857, 10.1038/s41467-023-42576-w · DOI
- Xu, 2021, Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation, Cell Rep., 36, 10.1016/j.celrep.2021.109343 · DOI
Cited by
Sorted by citations
Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions
Schmid, E. W., & Walter, J. C. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.01.034 · Cited by 120
Zainu, A., Dupaigne, P., Bouchouika, S., Cau, J., Clément, J. A. J., Auffret, P., Ropars, V., Charbonnier, J., de Massy, B., Mercier, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51458-8 · Cited by 22
“FIGNL1 ( fi dgetin-like 1) forms an evolutionary conserved complex with FIRRM (FIGNL1 interacting regulator of recombination and mitosis) that interacts with RAD51 and DMC1, and regulates negatively RAD51 during HR repair in mammalian cells 43 – 51 .”
BackgroundExtensive homologous recombination safeguards oocyte genome integrity in mammals
Cao, H., Qiu, C., Fang, A., Shang, J., Xu, W., He, L., Duan, X., Zhang, Q., & Yu, C. Y. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1304 · Cited by 9
The Role of MACIR Gene in Regulation of Immune Response and Pathogenesis of Disease
Plewa, P., Figiel, K., Jędrasiak, A., Ostałowska, H., Szulc, J., Krawczyk, I., & Pawlik, A. (2026) · Genes · doi:10.3390/genes17111364
Nishiguchi, D., Takahashi, Y., Tani, N., Nishizaki, Y., Tatsukawa, K., Kawasoe, Y., Ishiguro, K.-I., Kanemaki, M. T., & Takahashi, T. S. (2026) · bioRxiv · doi:10.64898/2026.10.19.760033
Ikehara, T., Otsu, H., Tobo, T., Hosoda, K., Hirose, K., Ofuchi, T., Tsujimoto, A., Shibuta, S., Kawata, K., Itoyama, S., et al. (2026) · Journal of gastroenterology · doi:10.1007/s00535-026-02380-x
“FIRRM is overexpressed in different cancers, and its high expression correlates with reduced survival in specific cancer types [38].”
Xu, W., Shen, M., Ma, J., Peng, C., Wu, S.-S., Yang, X.-X., Wu, J.-H., Yan, Y.-Y., Lin, N., Gao, J.-Q., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.09.042
“RAD51 facilitates the search for homologous DNA sequences and strand invasion steps essential for HR 51 .”
Metadata
- Authors
- Tsaridou, S., & van Vugt, M. A. T. M.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- van Vugt, Marcel A.T.M.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 40
- Issue
- 6
- Pages
- 467-470
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W4392879848
- Cited by
- 8
- References
- 15
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Funders
- NWO
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- FIGNL1, homologous recombination, RAD51, DNA repair, genome stability, strand invasion, homology search, carcinogenesis, protein regulation
- MeSH terms
- Animals, DNA Repair, Humans, Genomic Instability, Rad51 Recombinase, Homologous Recombination
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