The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Error thresholds and the constraints to RNA virus evolution
Open accessAbstract
RNA viruses are often thought of as possessing almost limitless adaptability as a result of their extreme mutation rates. However, high mutation rates also put a cap on the size of the viral genome by establishing an error threshold, beyond which lethal numbers of deleterious mutations accumulate. Herein, I argue that a lack of genomic space means that RNA viruses will be subject to important evolutionary constraints because specific sequences are required to encode multiple and often conflicting functions. Empirical evidence for these constraints, and how they limit viral adaptability, is now beginning to accumulate. Documenting the constraints to RNA virus evolution has important implications for predicting the emergence of new viruses and for improving therapeutic procedures.
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Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
Mutation rates among RNA viruses
Drake, J. W., & Holland, J. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13910 · Cited by 1,143
Cited by
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Yurkovetskiy, L., Wang, X., Pascal, K. E., Tomkins-Tinch, C., Nyalile, T. P., Wang, Y., Baum, A., Diehl, W. E., Dauphin, A., Carbone, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.032 · Cited by 1,025
Wilkinson, T. M., Li, C. K. F., Chui, C. S. C., Huang, A. K. Y., Perkins, M., Liebner, J. C., Lambkin-Williams, R., Gilbert, A., Oxford, J., Nicholas, B., et al. (2012) · Nature Medicine · doi:10.1038/nm.2612 · Cited by 974
Hillman, B. I., & Cai, G. (2013) · Advances in Virus Research · doi:10.1016/b978-0-12-394315-6.00006-4 · Cited by 269
The contribution of epistasis to the architecture of fitness in an RNA virus
Sanjuán, R., Moya, A., & Elena, S. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404125101 · Cited by 233
Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L
Goldstein, S. A., & Elde, N. C. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312691121 · Cited by 9
Metadata
- Authors
- Holmes, E. C.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 11
- Issue
- 12
- Pages
- 543-546
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W1976576146
- Cited by
- 254
- References
- 3
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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