The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Evolution of virulence in opportunistic pathogens: generalism, plasticity, and control
Open accessAbstract
Standard virulence evolution theory assumes that virulence factors are maintained because they aid parasitic exploitation, increasing growth within and/or transmission between hosts. An increasing number of studies now demonstrate that many opportunistic pathogens (OPs) do not conform to these assumptions, with virulence factors maintained instead because of advantages in non-parasitic contexts. Here we review virulence evolution theory in the context of OPs and highlight the importance of incorporating environments outside a focal virulence site. We illustrate that virulence selection is constrained by correlations between these external and focal settings and pinpoint drivers of key environmental correlations, with a focus on generalist strategies and phenotypic plasticity. We end with a summary of key theoretical and empirical challenges to be met for a fuller understanding of OPs.
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Cites
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Gould, S. J., & Lewontin, R. C. (1979) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1979.0086 · Cited by 7,770
Antibiotic resistance is ancient
D’Costa, V. M., King, C. E., Kalan, L., Morar, M., Sung, W. W. L., Schwarz, C., Froese, D., Zazula, G., Calmels, F., Debruyne, R., et al. (2011) · Nature · doi:10.1038/nature10388 · Cited by 2,720
Cooperation and competition in pathogenic bacteria
Griffin, A. S., West, S. A., & Buckling, A. (2004) · Nature · doi:10.1038/nature02744 · Cited by 1,104
Cited by
Microbiome definition re-visited: old concepts and new challenges
Berg, G., Rybakova, D., Fischer, D., Cernava, T., Vergès, M.-C. C., Charles, T., Chen, X., Cocolin, L., Eversole, K., Corral, G. H., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00875-0 · Cited by 2,275
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Self-citationMicrobial evolution and transitions along the parasite–mutualist continuum
Drew, G. C., Stevens, E. J., & King, K. C. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00550-7 · Cited by 339
Transmission modes of the mammalian gut microbiota
Moeller, A. H., Suzuki, T. A., Phifer-Rixey, M., & Nachman, M. W. (2018) · Science · doi:10.1126/science.aat7164 · Cited by 292
Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans
Desjardins, C. A., Giamberardino, C., Sykes, S. M., Yu, C.-H., Tenor, J. L., Chen, Y., Yang, T., Jones, A. M., Sun, S., Haverkamp, M. R., et al. (2017) · Genome Research · doi:10.1101/gr.218727.116 · Cited by 157
Metadata
- Authors
- Brown, S. P., Cornforth, D. M., & Mideo, N.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 20
- Issue
- 7
- Pages
- 336-342
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W1982276718
- Cited by
- 416
- References
- 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brown, S. P., Cornforth, D. M., & Mideo, N. (2012). Evolution of virulence in opportunistic pathogens: generalism, plasticity, and control. Trends in Microbiology. https://doi.org/10.1016/j.tim.2012.04.005
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