The gut microbiome, probiotics, bile acids axis, and human health
Abstract
The human gut microbiome produces potent ligands to bile acid receptors, and probiotics could act as therapeutics of bile acid dysmetabolism. A recent study in Cell Reports demonstrates that probiotic VSL#3 affects bile acid deconjugation and excretion, as well as the gut-liver FXR-FGF15 axis.
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Primary bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids via deconjugation, dehydrogenation, and dehydroxylation in the gut.
“Primary BAs are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary BAs via deconjugation, dehydrogenation, and dehydroxylation in the gut (6).”
The gut microbiota regulates secondary bile acid metabolism and bile acid synthesis in the liver by alleviating the enterohepatic FXR-FGF15 axis.
“Furthermore, many studies have shown that the gut microbiota regulates secondary BA metabolism and BA synthesis in the liver by alleviating the enterohepatic FXR-fibroblast growth factor 15 (FGF15) axis (6, 9).”
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References 10 · Cited by 64
- Authors
- Jones, M. L., Tomaro-Duchesneau, C., & Prakash, S.
- Affiliations
- McGill University (CA)
- Corresponding author
- Prakash, Satya
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 22
- Issue
- 6
- Pages
- 306-308
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W1975566317
- Cited by
- 64
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 3
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- gut microbiota, probiotics, bile acids, bile acid receptors, bile acid deconjugation, bile acid excretion, VSL#3, farnesoid X receptor, FGF15, gut-liver axis, human health
- MeSH terms
- Bile Acids and Salts, Humans, Ligands, Models, Biological, Probiotics, Microbiota
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