Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?
Abstract
Esophageal adenocarcinoma develops through a cascade of cellular changes that shares similarities to the etiology of Helicobacter pylori-associated intestinal-type gastric adenocarcinoma. While host genetics and immune response have been implicated in the progression to esophageal adenocarcinoma, studies investigating esophageal microbial communities suggest that bacteria may also play an important role in driving the inflammation that leads to disease. Of these, emerging Campylobacter species have been found to be more prevalent and abundant in patients progressing through the esophageal adenocarcinoma cascade compared to controls. Given that these bacteria possess several virulence mechanisms such as toxin production, cellular invasion, and intracellular survival, emerging Campylobacter species should be investigated as etiological agents of the chronic esophageal inflammation that leads to cancer.
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Campylobacter concisus could have a role in EAC, promoting the metaplastic processes in the early stages of cancer through an increase in IL-18 expression and downregulation of TGF-beta1, NF-κB and STAT3 signaling involved in the EAC cascade.
“This bacterium could have a role in EAC, promoting the metaplastic processes in the early stages of cancer through an increase in the interleukin (IL)-18 expression and downregulation of transforming growth factor beta 1, nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 signaling involved in the EAC cascade[42-44].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [44]
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References 68 · Cited by 62
- Authors
- Kaakoush, N. O., Castaño-Rodríguez, N., Man, S. M., & Mitchell, H. M.
- Affiliations
- UNSW Sydney (AU)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Kaakoush, Nadeem O.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 23
- Issue
- 8
- Pages
- 455-462
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2063879412
- Cited by
- 62
- References
- 68
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 14 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- Campylobacter, esophageal adenocarcinoma, Helicobacter pylori, gastric adenocarcinoma, bacterial virulence factors, toxin production, cell invasion, intracellular survival, esophageal microbiome, cancer etiology, host genetics, immune response
- MeSH terms
- Adenocarcinoma, Campylobacter Infections, Esophageal Neoplasms, Humans, Stomach Neoplasms, Helicobacter Infections
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