Current Trends in Methylotrophy
Open accessAbstract
Methylotrophy is a field of study dealing with microorganisms capable of utilization of compounds devoid of carbon-carbon bonds (C1 compounds). In this review, we highlight several emerging trends in methylotrophy. First, we discuss the significance of the recent discovery of lanthanide-dependent alcohol dehydrogenases for understanding both the occurrence and the distribution of methylotrophy functions among bacteria, and then we discuss the newly appreciated role of lanthanides in biology. Next, we describe the detection of other methylotrophy pathways across novel bacterial taxa and insights into the evolution of methylotrophy. Further, data are presented on the occurrence and activity of aerobic methylotrophs in hypoxic and anoxic environments, questioning the prior assumptions on niche separation of aerobic and anaerobic methylotrophy. The concept of communal function in aerobic methane oxidation is also briefly discussed. Finally, we review recent research in engineering methylotrophs for biotechnological applications as well as recent progress in engineering synthetic methylotrophy.
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Several other studies uncovered further examples in which individual genes of the archaeal methyl synthesis and methanopterin pathways had been transferred from archaea to bacterial recipients, which are often O2-dependent methylotrophs and methanotrophs.
“Several other studies uncovered further examples in which individual genes of the archaeal methyl synthesis and methanopterin pathways had been transferred from archaea to bacterial recipients [50, 151, 152, 153, 154], which are often O2‐dependent methylotrophs and methanotrophs.”
From Evidence for corrin biosynthesis in the last universal common ancestor (2025) · cites this paper as [153]
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References 108 · Cited by 168
- Authors
- Chistoserdova, L., & Kalyuzhnaya, M. G.
- Affiliations
- University of Washington (US)
- San Diego State University (US)
- Corresponding author
- Chistoserdova, Ludmila
- Kalyuzhnaya, Marina G.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 26
- Issue
- 8
- Pages
- 703-714
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2788816250
- Cited by
- 168
- References
- 108
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 18 · 2023: 11 · 2022: 14 · 2021: 32 · 2020: 20 · 2019: 29 · 2018: 9
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 349 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Trends in Microbiology (acceptedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- US Department of Energy, Office of Science, Office of Biological and Environmental Research (DE-SC-0016224)
- National Science Foundation (CBET-1605031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Physical Sciences › Environmental Science › Environmental Chemistry › Methane Hydrates and Related Phenomena
- Keywords
- methylotrophy, C1 compounds, methylotrophic bacteria, aerobic methane oxidation, biotechnology applications
- MeSH terms
- Alcohol Dehydrogenase, Alcohol Oxidoreductases, Anaerobiosis, Bacteria, Genetic Engineering, Methane, Oxidation-Reduction, Lanthanoid Series Elements
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