The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
Open accessAbstract
Despite the recent advances in controlling some viral pathogens, most viral infections still lack specific treatment. Indeed, the need for effective therapeutic strategies to combat ‘old’, emergent, and re-emergent viruses is not paralleled by the approval of new antivirals. In the past years, drug repurposing combined with innovative approaches for drug validation, and with appropriate animal models, significantly contributed to the identification of new antiviral molecules and targets for therapeutic intervention. In this review, we describe the main strategies of drug repurposing in antiviral discovery, discuss the most promising candidates that could be repurposed to treat viral infections, and analyze the possible caveats of this trendy strategy of drug discovery.
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Citations
Cites
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
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Cited by
Naqvi, A. A. T., Fatima, K., Mohammad, T., Fatima, U., Singh, I. K., Singh, A., Atif, S. M., Hariprasad, G., Hasan, G. M., & Hassan, M. I. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165878 · Cited by 1,114
Clinical trials on drug repositioning for COVID-19 treatment
Rosa, S. G. V., & Santos, W. C. (2020) · Revista Panamericana de Salud Pública · doi:10.26633/rpsp.2020.40 · Cited by 420
Pizzorno, A., Padey, B., Terrier, O., & Rosa-Calatrava, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00531 · Cited by 122
“This interest is inversely correlated with the very low number of classic antiviral molecules that have been market-approved these last 5 years, mostly for the treatment of hepatitis C virus or HIV-related pathologies (72).”
BackgroundDrug repurposing to fight colistin and carbapenem-resistant bacteria
Peyclit, L., Baron, S. A., & Rolain, J.-M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00193 · Cited by 91
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Metadata
- Authors
- Mercorelli, B., Palù, G., & Loregian, A.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 26
- Issue
- 10
- Pages
- 865-876
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2800221771
- Cited by
- 264
- References
- 67
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mercorelli, B., Palù, G., & Loregian, A. (2018). Drug Repurposing for Viral Infectious Diseases: How Far Are We? Trends in Microbiology. https://doi.org/10.1016/j.tim.2018.04.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
