Arc in synaptic plasticity: from gene to behavior
Open accessAbstract
The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity controls Arc mRNA induction, trafficking and accumulation, and Arc protein production, localization and stability. Arc regulates synaptic strength through multiple mechanisms and is involved in essentially every known form of synaptic plasticity. It also mediates memory formation and is implicated in multiple neurological diseases. In this review, we will discuss how Arc is regulated and used as a tool to study neuronal activity. We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions.
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Activation of mTORC1 leads to translation of synaptic proteins that are important molecular contributors to memory processes.
“Furthermore, we show that the activation of mTORC1 leads to the translation of synaptic proteins that are important molecular contributors to memory processes32-35.”
From Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse (2013) · cites this paper as [34]
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References 85 · Cited by 388
- Authors
- Korb, E., & Finkbeiner, S.
- Affiliations
- Gladstone Institutes (US)
- Corresponding author
- Finkbeiner, Steven
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 34
- Issue
- 11
- Pages
- 591-598
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3207967
- OpenAlex
- W1965970232
- Cited by
- 388
- References
- 85
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 51 · 2023: 26 · 2022: 23 · 2021: 33 · 2020: 17 · 2019: 22 · 2018: 40 · 2017: 30 · 2016: 19 · 2015: 20 · 2014: 19 · 2013: 34 · 2012: 18
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Hellman Foundation
- Hellman Family Foundation
- National Institute on Aging (P01AG022074)
- National Institute of Mental Health (F31MH087009)
- National Institute of Neurological Disorders and Stroke (R01NS039074)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Arc gene, synaptic plasticity, memory consolidation, neuronal activity regulation, synaptic efficacy, memory formation, neurological disorders, behavior
- MeSH terms
- Behavior, Cytoskeletal Proteins, Homeostasis, Humans, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Synapses, Transcription, Genetic, Signal Transduction
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