NMNATs, evolutionarily conserved neuronal maintenance factors
Open accessAbstract
Proper brain function requires neuronal homeostasis over a range of environmental challenges. Neuronal activity, injury, and aging stress the nervous system, and lead to neuronal dysfunction and degeneration. Nevertheless, most organisms maintain healthy neurons throughout life, implying the existence of active maintenance mechanisms. Recent studies have revealed a key neuronal maintenance and protective function for nicotinamide mononucleotide adenylyl transferases (NMNATs). We review evidence that NMNATs protect neurons through multiple mechanisms in different contexts, and highlight functions that either require or are independent of NMNAT catalytic activity. We then summarize data supporting a role for NMNATs in neuronal maintenance and raise intriguing questions on how NMNATs preserve neuronal integrity and facilitate proper neural function throughout life.
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NMNATs show neuroprotective effects in mouse and Drosophila models.
“Three mammalian NMNATs exist, NMNAT1–3, showing neuroprotective effects in both mice and D. melanogaster models (Ali et al., 2013).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Ali et al., 2013
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References 97 · Cited by 91
- Authors
- Ali, Y. O., Li-Kroeger, D., Bellen, H. J., Zhai, R. G., & Lu, H.-C.
- Affiliations
- Baylor College of Medicine (US)
- Howard Hughes Medical Institute (US)
- University of Miami (US)
- Corresponding author
- Ali, Yousuf O.
- Lu, Hui-Chen
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 36
- Issue
- 11
- Pages
- 632-640
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3857727
- OpenAlex
- W1995737466
- Cited by
- 91
- References
- 97
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 14 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Pew Charitable Trusts
- University of Miami
- National Institutes of Health
- National Institute on Drug Abuse (K05DA021696)
- National Institute of Neurological Disorders and Stroke (R01NS048884, T32NS043124, R01NS064269, R56NS064269, NS048884, NS64269)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD065561, R21HD065561)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- nicotinamide mononucleotide adenylyltransferase, neuronal maintenance, neuronal homeostasis, neuroprotection, neurodegeneration, aging, neuronal injury
- MeSH terms
- Animals, Humans, Nerve Degeneration, Neurons, Nicotinamide Mononucleotide, Nucleotidyltransferases, Evolution, Molecular, Biocatalysis
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