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Cited by 147Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorHistorical and Modern Theater Studies

Neural Substrates of Inhibitory Control Maturation in Adolescence

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Constantinidis, Christos, Luna, Beatriz·2019·Trends in Neurosciences
DOI 10.1016/j.tins.2019.07.004PMC PMC6721973
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Abstract

Inhibitory control matures through adolescence and into early adulthood, impacting decision-making. Impairments in inhibitory control are associated with various psychopathologies, many of which emerge during adolescence. In this review, we examine the neural basis of developmental improvements in inhibitory control by integrating findings from humans and non-human primates, identifying the structural and functional specialization of executive brain systems that mediates cognitive maturation. Behavioral manifestations of response inhibition suggest that adolescents are capable of producing adult level responses on occasion, but lack the ability to engage systems mediating response inhibition in a consistent fashion. Maturation is associated with changes in structural anatomy as well as local and systems-level connectivity. Functional changes revealed by neuroimaging and neurophysiology indicate that maturation of inhibitory control is achieved through improvements in response preparation, error processing, and planned responses.

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  • Inhibitory control is a psychological construct closely related to neural development and cognitive processes that vary by levels of positive parenting and is not directly influenced by material resources.

    “It underscores that inhibitory control is a psychological construct closely related to neural development and cognitive processes that vary by levels of positive parenting and is not directly influenced by material resources (e.g., Constantinidis and Luna, 2019).”

    From Towards a better understanding of inequity and the psychological processes underlying the intergenerational transmission of socioeconomic status (2024) · cites this paper as Constantinidis and Luna, 2019

    The Behavioral manifestations of inhibitory control section (page unavailable) links inhibitory performance to neural and executive processes, and the Concluding Remarks (page unavailable) describe their maturation. The paper does not address whether inhibitory control varies with positive parenting or whether material resources directly influence it; searches for those terms found no supporting passage. (LLM, conf=0.90)

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  • Cognitive skills such as planning, future thinking, inhibiting inappropriate behaviour, emotion regulation, decision making, and particular forms of memory continue to improve during adolescence.

    “At the same time, cognitive skills such as planning, future thinking, inhibiting inappropriate behaviour, emotion regulation, decision making, and particular forms of memory continue to improve during adolescence (figure 2). 144-149”

    From The Lancet Psychiatry Commission on youth mental health (2024) · cites this paper as [145]

    The Behavioral manifestations of inhibitory control section reports continued improvement in response inhibition through adolescence, and the Concluding Remarks say working memory continues to mature. The paper also discusses planning effective responses, but the passages do not establish adolescent improvement in future thinking or emotion regulation; it says inhibitory control impacts decision making rather than showing that decision-making skills improve. (LLM, conf=0.88)

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References 92 · Cited by 147

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Authors
Constantinidis, C., & Luna, B.
Affiliations
Wake Forest University Health Sciences (US)
Corresponding author
Constantinidis, Christos
ORCID
Constantinidis, Christos
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2019-09
Volume
42
Issue
9
Pages
604-616
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2019.07.004
PMC
PMC6721973
OpenAlex
W2969833038
Cited by
147
References
92
Citations by year
2026: 16 · 2025: 25 · 2024: 24 · 2023: 28 · 2022: 17 · 2021: 24 · 2020: 11 · 2019: 2
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
inhibitory control, cognitive maturation, adolescence, response inhibition, executive function, neural correlates, brain connectivity, brain structural changes, error processing, response preparation, non-human primates, decision-making
MeSH terms
Adolescent, Brain, Brain Mapping, Cognition, Humans, Magnetic Resonance Imaging, Synaptic Transmission, Executive Function

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