Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications

Khoury, Joseph El, Luster, Andrew D.·2008·Trends in Pharmacological Sciences

Cited by (172)

Items 101–172 of 172

  1. Role of CCR2 in immunobiology and neurobiology
    Ryo Yamasaki, Liping Liu, Jessica Lin, Richard M. Ransohoff · 2011 · Clinical and Experimental Neuroimmunology
  2. Cerebrospinal Fluid C-C Motif Chemokine Ligand 2 Correlates with Brain Atrophy and Cognitive Impairment in Alzheimer’s Disease
    Akio Kimura, Nobuaki Yoshikura, Yuichi Hayashi, Takashi Inuzuka · 2017 · Journal of Alzheimer s Disease
  3. CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis
    Julien Bruban, Agathe Maoui, Naïma Chalour, Na An, Laurent Jonet, Charles Feumi, Jacques Tréton, Florian Sennlaub, Francine Béhar‐Cohen, Frédéric Mascarelli et al. · 2011 · Neurobiology of Disease
  4. Glia-based biomarkers and their functional role in the CNS
    Mithilesh Kumar Jha, Kyoungho Suk · 2013 · Expert Review of Proteomics
  5. Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation
    Robert M. J. Deacon, Francisco J. Altimiras, Enrique A. Bazán-León, Radha Devi Pyarasani, Fabiane M. Nachtigall, Leonardo S. Santos, Anthony George Tsolaki, Lina Pednekar, Uday Kishore, Rodolfo R. Biekofsky et al. · 2015 · Current Alzheimer Research
  6. The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease
    Robert A. Culibrk, Mariah S. Hahn · 2020 · Frontiers in Aging Neuroscience
  7. Oligomeric Aβ-Induced Microglial Activation is Possibly Mediated by NADPH Oxidase
    Juan Li, Jingyu Yang, Xue Yao, Xue Xue, Qing Chun Zhang, Xiao Xiao Wang, Ling Ding, Chun Fu Wu · 2012 · Neurochemical Research
  8. Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice
    Julie Vérité, Thierry Janet, Damien Chassaing, Bernard Fauconneau, Hanitriniaina Rabeony, Guylène Page · 2018 · Journal of Neuroinflammation
  9. Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases
    Yidan Zhang, Yifan Wang, Zhan Zhao, Weixun Peng, Peng Wang, Ximing Xu, Chenyang Zhao · 2022 · European Journal of Pharmacology
  10. Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers
    Kyoungho Suk · 2010 · Expert Review of Proteomics
  11. Probiotics improve insulin resistance status in an experimental model of Alzheimer’s disease
    Somayeh Athari Nik Azm, Abolghassem Djazayeri, Majid Safa, Kian Azami, Mahmoud Djalali, Mohammad Sharif Sharifzadeh, Mohammadreza Vafa · 2017 · Medical Journal of the Islamic Republic of Iran
  12. CCR2 Plays a Protective Role in Rocio Virus–Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain
    Alberto Anastacio Amarilla, Nilton Nascimento Santos-Júnior, Mário Luis Garcia de Figueiredo, João Paulo Mesquita Luiz, Marcílio Jorge Fumagalli, David Fernando Colón, Veronica Lippi, Helda Liz Alfonso, Djalma Souza Lima-Junior, Amanda Cristina Trabuco et al. · 2019 · The Journal of Infectious Diseases
  13. Targeting the hematopoietic system for the treatment of Alzheimer’s disease
    Antoine Lampron, David Gosselin, Serge Rivest · 2010 · Brain Behavior and Immunity
  14. P2Y13 Receptor-Mediated Rapid Increase in Intracellular Calcium Induced by ADP in Cultured Dorsal Spinal Cord Microglia
    Junwei Zeng, Gaoxia Wang, Xiaohong Liu, Chunmei Wang, Hong Wei Tian, Aidong Liu, Huan Jin, Xiaomei Luo, Yuan‐Shou Chen · 2014 · Neurochemical Research
  15. Regulatory Roles of Bone in Neurodegenerative Diseases
    Zhengran Yu, Zemin Ling, Lu Lin, Jin Xia Zhao, Xiang Chen, Pingyi Xu, Xuenong Zou · 2020 · Frontiers in Aging Neuroscience
  16. Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer’s disease
    Elisa Porcellini, Manuela Ianni, Ilaria Carbone, M. Franceschi, Federico Licastro · 2013 · Immunity & Ageing
  17. Curcumin Ameliorates the Reduction Effect of PGE2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells
    Genlin He, Zhen Luo, Ju Yang, Tingting Shen, Yi Chen, Xuesen Yang · 2016 · PLoS ONE
  18. Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains
    Gamache, Julia, Gingerich, Daniel, Shwab, E. Keats, Barrera, Julio, Garrett, Melanie E., Hume, Cordelia, Crawford, Gregory E., Ashley-Koch, Allison E., Chiba-Falek, Ornit · 2023 · Cell & Bioscience
  19. Amyloidogenic Properties of a D/N Mutated 12 Amino Acid Fragment of the C-Terminal Domain of the Cholesteryl-Ester Transfer Protein (CETP)
    Víctor García‐González, Jaime Mas‐Oliva · 2011 · International Journal of Molecular Sciences
  20. Bone Tissue and the Nervous System: What Do They Have in Common?
    Arianna Minoia, Luca Dalle Carbonare, Jens Christian Schwamborn, Silvia Bolognin, Maria Teresa Valenti · 2022 · Cells
  21. GLP-1/Sigma/RAGE receptors: An evolving picture of Alzheimer's disease pathology and treatment
    Neha Neha, Zitin Wali, Pinky Pinky, Shaheenkousar H. Hattiwale, Azfar Jamal, Suhel Parvez · 2023 · Ageing Research Reviews
  22. Peripheral Blood-Derived Microglia-Like Cells Decrease Amyloid-β Burden and Ameliorate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
    Eriko Kuroda, Kazuyuki Takata, Kaneyasu Nishimura, Hikaru Oka, Mari Sueyoshi, Mayu Aitani, Atsushi Kouda, Shiho Satake, Chiaki Shima, Yuki Toda et al. · 2019 · Journal of Alzheimer s Disease
  23. Ccr2-64i and Ccr5 Δ32 Polymorphisms in Patients with Late-Onset Alzheimer's disease; A Study from Iran (Ccr2-64i And Ccr5 Δ32 Polymorphisms in Alzheimer's disease).
    Hamid Reza Khorram Khorshid, Mehdi Manoochehri, Leila Nasehi, Mina Ohadi, Mehdi Rahgozar, Koorosh Kamali · 2012 · Europe PMC (PubMed Central)
  24. Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation
    Yue Jin Yang, Nikolas L. Jorstad, Christine Shiao, Makenzie K. Cherne, Shawn B. Khademi, Kathleen S. Montine, Thomas Jude Montine, Christopher Dirk Keene · 2013 · Experimental and Molecular Pathology
  25. Non-coding RNAs involved in the molecular pathology of Alzheimer’s disease: a systematic review
    Reynand Jay Canoy, Jenica Clarisse Sy, Christian Deo T. Deguit, Caitlin Bridgette Castro, Lyoneil James Dimaapi, Beatrice Gabrielle T. Panlaqui, Wenzel Perian, Justine R. Yu, John Mark Velasco, Jesus Emmanuel Sevilleja et al. · 2024 · Frontiers in Neuroscience
  26. Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report
    Carlos Henrique Ferreira Camargo, Filipe Fernandes Justus, Giuliano Retzlaff, Marcelo Rezende Young Blood, Marcelo Derbli Schafranski · 2015 · Dementia & Neuropsychologia
  27. Triggering receptor expressed on myeloid cells 2 activation downregulates toll‐like receptor 4 expression and ameliorates cognitive impairment in the Aβ1‐42‐induced Alzheimer's disease mouse model
    Zhangjin Qin, Min Gu, Jian Zhou, Wenbo Zhang, Nan Zhao, Yang Lü, Weihua Yu · 2020 · Synapse
  28. Amyloid-Beta-Activated Human Microglial Cells Through ER-Resident Proteins
    YongCheol Yoo, Kyunghee Byun, Taewook Kang, Delger Bayarsaikhan, Jin Young Kim, Seyeoun Oh, Young Hye Kim, Se Young Kim, Wonil Chung, Seung Up Kim et al. · 2014 · Journal of Proteome Research
  29. The role of glial cells and the complement system in retinal diseases and Alzheimer’s disease: common neural degeneration mechanisms
    Hannah Harvey, Szonya Durant · 2014 · Experimental Brain Research
  30. Emerging advances in nano-biomaterial assisted amyloid beta chimeric antigen receptor macrophages (CAR-M) therapy: reducing plaque burden in Alzheimer’s disease
    Nishabh Kushwaha, Drishti Panjwani, Shruti Patel, Priyanka Ahlawat, Mange Ram Yadav, Asha Patel · 2024 · Journal of drug targeting
  31. Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism.
    R. Abdel-Aal, Ola A. Hussein, Reham G. Elsaady, Lobna A. Abdelzaher · 2021 · European Journal of Pharmacology
  32. Role of TGF-β Signaling in Neurogenic Regions After Brain Injury
    Sonia Villapol, T. Trevor, J. Aviva · 2013 · InTech eBooks
  33. The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease.
    Sonia Podvin, Miles C. Miller, Ryan Rossi, Jasmine Chukwueke, John Edward Donahue, Conrad E. Johanson, Andrew Baird, Edward G. Stopa · 2016 · PubMed
  34. Differential chemokine expression under the control of peripheral blood mononuclear cells issued from Alzheimer’s patients in a human blood brain barrier model
    Julie Vérité, Guylène Page, Marc Paccalin, Adrien Julian, Thierry Janet · 2018 · PLoS ONE
  35. Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice
    Zhizhang Dong, Juan Li, Yunxia Leng, Xuerong Sun, Huiling Hu, Yuan He, Zhiqun Tan, Jian Ge · 2012 · BMC Neuroscience
  36. Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases
    Magdalena Sastre, Loukia Katsouri, Amy M. Birch, Alexander Renziehausen, David Trevor Dexter, Robert R. Crichton, Roberta J. Ward · 2014 · Wiley eBooks
  37. Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells
    Juliana Falero-Perez, Nader Sheibani, Christine M. Sorenson · 2020 · PLoS ONE
  38. Close Association of Myeloperoxidase-Producing Activated Microglia with Amyloid Plaques in Hypercholesterolemic Rabbits
    Yuanxin Chen, TianDuo Wang, Kem A. Rogers, Brian K. Rutt, John Andrew Ronald · 2019 · Journal of Alzheimer s Disease
  39. Alteration of Cognitive Function in Aging and Alzheimer’s Disease Mice Is Related to Dysfunction of the Neuroimmune System
    Wanrong Jiang, Wei Wu, Li‐Jie Yang, Wanzhexi Yang, Qing Tian, Zhaohui Yao · 2023 · Journal of Alzheimer s Disease
  40. Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer’s and Parkinson’s disease
    Anwesha Bhattacharya, Edward A. Fon, Alain Dagher, Yasser Iturria‐Medina, Jo Anne Stratton, Chloé Savignac, Jack Stanley, L. M. Hodgson, Badr Ait Hammou, David A. Bennett et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Iron Oxide Nanoparticles Application in Toxicity Therapeutics of CNS Disorders Indicated by Molecular MRI
    Lei Zhao, Tao Peng, Shawn Wu · 2025 · Nanotechnology and nanomaterials.
  42. Therapeutic Potential of Experimental Stereotactic Hippocampal Cell Transplant in the Management of Alzheimer’s Disease
    Loredana Mariana Agavriloaei, Bogdan Florin Iliescu, Robert Mihai Pintilie, Mihaela Dana Turliuc · 2025 · Journal of Clinical Medicine
  43. α7-Nicotinic Acetylcholine Receptors and β-Amyloid Peptides in Alzheimer’s Disease
    Dietrich Ernst Lorke, Georg A. Petroianu, Murat Öz · 2016 · Neuromethods
  44. Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer’s and Parkinson’s disease
    Anwesha Bhattacharya, Edward A. Fon, Alain Dagher, Yasser Iturria‐Medina, Jo Anne Stratton, Chloé Savignac, Jack Stanley, L. M. Hodgson, Badr Ait Hammou, David A. A Bennett et al. · 2026 · GigaScience
  45. Biomarkers of Alzheimer’s disease
    Jason E. Pitt · 2014 · Elsevier eBooks
  46. The Potential Role of Naproxen in Promoting Rivastigmine Effect Against Aluminum Chloride-Induced Alzheimer-Like Model in Rats
    Raafat A. Abdel‐Aal, Ola A. Hussein, Reham G. Elsaady, Lobna A. Abdelzaher · 2021 · Research Square
  47. Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids
    Catarina Monteiro Gomes, Daniel F. Simão, Carolina Cardoso Gonçalves, Gabriela Priscila de Lima Silva, Beatriz Painho, Paula M. Alves, Catarina Brito · 2025 · iScience
  48. Brain-targeting nanocages treat Alzheimer’s disease via regulating microglial polarization and remodeling microenvironment
    Han Yang, Xiaowei Zhao, Min Liu, Xiaofang Li, Siyi Liu, Jingya Xiu, Dan Li, Jiulong Zhang, Xiuli Zhao · 2025 · International Journal of Pharmaceutics
  49. Aggregation of microglia in 2D with string gradient weighted moving finite elements
    Abigail Wacher, Simon Kaja · 2012 · Mathematical Methods in the Applied Sciences
  50. Possible Therapeutic Targets in Microglia
    Mami Noda · 2014 · Springer eBooks
  51. Characterization of the Role of Nicotine and Delta 9-THC in Modulation of Neuroinflammation
    Jared C. Ehrhart · 2010 · Digital Commons - University of South Florida (University of South Florida)
  52. Microglia demostrate age-dependent performance and interaction with beta-amyloid peptide
    Gonçalo Manuel da Costa Lidónio, Dora Maria Tuna Oliveira Brites, Deodália Maria Antunes Dias · 2013 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  53. Implications of Human Umbilical Cord Blood Cells: An Immunotherapeutic Strategy for Alzheimer's Disease
    Donna Darlington · 2014 · Digital Commons - University of South Florida (University of South Florida)
  54. Interactions Between Neurons and Microglia During Neuroinflammation
    Akio Suzumura · 2013 · Advances in neurobiology
  55. Human APOE4 affects microglial reactivity and spatial cognition in a mouse model of alzheimer's disease risk
    Gustavo A. Rodriguez · 2014 · DigitalGeorgetown (Georgetown University Library)
  56. Alleviation of central accumulation of amyloid-beta and prevention of cognitive dysfunction following peripheral inflammation
    Marielle Kahn Weintraub · 2014
  57. Bone Marrow–Derived Cells as Treatment Vehicles in the Central Nervous System
    Coral‐Ann B. Lewis, Fabio M V Rossi, Charles Krieger · 2011 · Humana Press eBooks
  58. Progressive multifokale Leukoenzephalopathie unter Therapie mit Natalizumab
    Juergen Faiss · 2015 · Springer eBooks
  59. Phenotypic Impact of Genetic Risk Pathways for Alzheimer's Disease
    Daniel Felsky · 2016 · TSpace (University of Toronto)
  60. Inflammatory pathology in neurodegenerative dementias
    Garry Niedermayer · 2014
  61. Morphological, functional and immunomodulatory effects of rosuvastatin and aspirin in cultured microglial cells
    D. Kata · 2017
  62. Faculty Opinions recommendation of Reimagining Alzheimer's disease--an age-based hypothesis.
    Безпрозванный Илья Борисович · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  63. Alzheimer Disease
    Andrew W. Kraft, Jin‐Moo Lee · 2012 · Oxford University Press eBooks
  64. Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains
    Julia Gamache, Daniel C. Gingerich, Elliot Keats Shwab, Julio Barrera, Melanie E. Garrett, Cordelia Hume, Gregory E. Crawford, Allison E. Ashley‐Koch, Ornit Chiba‐Falek · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  65. Role of probiotics in brain health
    Ajit Kumar Thakur, Nikhila Shekhar, Sakshi Tyagi, Sweta Rani · 2024 · Elsevier eBooks
  66. Intégrité de la barrière hémato-encéphalique et transport du peptide bêta-amyloïde dans la maladie d'Alzheimer
    Tuan Minh Do · 2012 · theses.fr (ABES)
  67. Métalloprotéases matricielles et maladie d'Alzheimer : étude du rôle de MT1-MMP dans le métabolisme de l'APP/Aß
    Nathalie A. Py · 2014 · theses.fr (ABES)
  68. Comparaison des effets de la viniférine et du resvératrol dans des modèles expérimentaux de la maladie d'Alzheimer
    Aline Freyssin · 2020 · theses.fr (ABES)
  69. Role of astrocytic calcium signaling in synaptic transmission, plasticity and memory : implications for neurodegenerative diseases
    Elsie Moukarzel · 2021 · theses.fr (ABES)
  70. Analgesic Modulation of Neuroendocrine and Region-Specific Neuropathological Responses Following Blast-Induced Traumatic Brain Injury in Rats
    Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Mital Y. Patel, Jishnu K.S. Krishnan, Deepak Menon, Chetan Y. Pundkar, Gaurav Phuyal, Laura M. Anderson, Sridhar Samineni, Joseph B. Long et al. · 2026 · Journal of Neurotrauma
  71. BindingDB Entry 50018244: Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors.
    BindingDB · 2024 · UC San Diego
  72. Toll-Like Receptor 2 and Partner Receptors in Alzheimers Disease
    Shirong, Liu · 2011 · Publications of the UdS (Saarland University)