Targeting Oxidative Stress in Central Nervous System Disorders
Open accessAbstract
There is widespread recognition that reactive oxygen species (ROS) play key roles in normal brain function and pathology in the context of neurological disease. Oxidative stress continues to be a key therapeutic target for neurological diseases. In developing antioxidant therapies for neurological disease, special attention should be given to the brain's unique vulnerability to oxidative insults and its architecture. Consideration of antioxidant therapy should be guided by a strong rationale for oxidative stress in a given neurological disease. This review provides an overview of processes that can guide the development of antioxidant therapies in neurological diseases, such as knowledge of basic redox mechanisms, unique features of brain pathophysiology, mechanisms and classes of antioxidants, and desirable properties of drug candidates.
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Discovery of antioxidant/anti-inflammatory drugs that effectively modulate oxidative stress has been hindered by the lack of effective pre-clinical models and understanding of molecular mechanisms that underpin neuroinflammation and ROS production.
“Discovery of antioxidant/anti-inflammatory drugs that effectively modulate oxidative stress has been hindered by the lack of effective pre-clinical models and understanding of molecular mechanisms that underpin neuroinflammation and ROS production [195].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [195]
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References 66 · Cited by 312
- Authors
- Patel, M.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Patel, Manisha
- ORCID
- Patel, Manisha
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 37
- Issue
- 9
- Pages
- 768-778
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC5333771
- OpenAlex
- W2486467989
- Cited by
- 312
- References
- 66
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 33 · 2021: 39 · 2020: 44 · 2019: 28 · 2018: 30 · 2017: 13 · 2016: 4
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS039587, R01NS086423, U01NS083422)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- oxidative stress, reactive oxygen species, antioxidant therapy, neurological disorders, central nervous system, redox mechanism, neuroprotection
- MeSH terms
- Animals, Brain, Brain Diseases, Humans, Reactive Oxygen Species, Oxidative Stress
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