The CRF system as a therapeutic target for neuropsychiatric disorders
Open accessAbstract
The major neuropsychiatric disorders are devastating illnesses that are only modestly responsive to treatment. Improving the treatment of these conditions will require innovative new strategies that depart from previously focused-on pharmacological mechanisms. Considerable preclinical and clinical data indicate corticotropin-releasing factor (CRF) signaling as a target for new psychotropic drug development. Here we review alterations in the CRF system reported in several psychiatric conditions. We also examine the preclinical work that has dissected the distinctive roles of CRF receptors in specific circuits relevant to these disorders. We further describe the clinical trials of CRF1 receptor antagonists that have been conducted. Although these clinical trials have thus far met with limited therapeutic success, the unfolding complexity of the CRF system promises many future directions for studying its role in the etiology and treatment of neuropsychiatric conditions.
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Increased CRF concentration in cerebrospinal fluid was reported in depressive patients and victims of suicide.
“Increased CRF concentration in the cerebrospinal fluid was also reported in depressive patients and victims of suicide [359,360].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [359]
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References 82 · Cited by 72
- Authors
- Sanders, J., & Nemeroff, C.
- Affiliations
- Emory University (US)
- University of Miami (US)
- Corresponding author
- Sanders, Jeff
- ORCID
- Nemeroff, Charles
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 37
- Issue
- 12
- Pages
- 1045-1054
- ISSN
- 0165-6147 (ISSN-L)
- PMC
- PMC5121012
- OpenAlex
- W2528156728
- Cited by
- 72
- References
- 82
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 2 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 14 · 2018: 9 · 2017: 7
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K08MH105754)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- corticotropin-releasing factor, CRF receptors, CRF1 receptor antagonist, neuropsychiatric disorders
- MeSH terms
- CRF Receptor, Type 1, Animals, Mental Disorders, Corticotropin-Releasing Hormone, Humans, Nervous System Diseases, Drug Design, Receptors, Corticotropin-Releasing Hormone, Molecular Targeted Therapy
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