Placental transfer and metabolism: An overview of the experimental models utilizing human placental tissue
Abstract
Over the decades several ex vivo and in vitro models which utilize delivered human placenta have been developed to study various placental functions. The use of models originating from human placenta to study transplacental transfer and related mechanisms is an attractive option because human placenta is relatively easily available for experimental studies. After delivery placenta has served its purpose and is usually disposed of. The purpose of this review is to give an overview of the use of human placental models for the studies on human placental transfer and related mechanisms such as transporter functions and xenobiotic metabolism. Human placental perfusion, the most commonly used continuous cell lines, primary cells and tissue culture, as well as subcellular fractions are briefly introduced and their major advantages and disadvantages are discussed.
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BeWo trophoblast cells serve as an in vitro model of the rate-limiting barrier of maternal-fetal exchange and can be used to study placental metabolism and transport of numerous substances, including IgG.
“These trophoblast cells serve as an in vitro model of the rate-limiting barrier of maternal–fetal exchange and can be used to study placental metabolism and transport of numerous substances, including IgG (134–136).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [134]
The placental perfusion model offers the best technique to study the transplacental exchange of substances across the intact human placenta.
“It does however offer the best technique to study the transplacental exchange of substances across the intact human placenta (134, 140).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [134]
The BeWo model is far less technically challenging to perform than the perfusion model, which requires very rapid access to fresh placenta samples and has a high failure rate.
“Despite its limitations, the BeWo model is far less technically challenging to perform than the perfusion model, which requires very rapid access to fresh placenta samples and has a high failure rate (134).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [134]
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References 66 · Cited by 115
- Authors
- Myllynen, P., & Vähäkangas, K.
- Affiliations
- University of Oulu (FI)
- University of Eastern Finland (FI)
- Corresponding author
- Vähäkangas, Kirsi
- ORCID
- Myllynen, Päivi
- Venue
- Toxicology in Vitro
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 27
- Issue
- 1
- Pages
- 507-512
- ISSN
- 0887-2333 (ISSN-L)
- OpenAlex
- W2020029636
- Cited by
- 115
- References
- 66
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 7 · 2014: 3 · 2013: 5
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology in Vitro (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NewGeneris (FOOD-CT: 2005-016320)
- ReProTect (LSHB-CT-2004-503257)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- human placenta, placental transfer, xenobiotic metabolism, placental transporters, placental perfusion, subcellular fractions, placental function
- MeSH terms
- Cell Line, Female, Humans, Maternal-Fetal Exchange, Models, Biological, Placenta, Pregnancy, Xenobiotics
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