What is understood by animal-free research
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Integrity signals
Registry
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Claims the paper makes
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Modern 3Rs interpretations in NAMs increasingly extend the 3Rs concept to animal-derived materials, advocating fully animal-free systems even in the absence of explicit regulatory obligations.
“In contrast, modern 3Rs interpretations in New Approach Methodologies (NAMs) increasingly extend the 3Rs concept to animal-derived materials, advocating fully animal-free systems even in the absence of explicit regulatory obligations (Oredsson et al., 2019; Rosolowski et al., 2025).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Oredsson et al., 2019
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Cites
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Research works printed but not linked: 2
- Törnqvist, E., Anas, A., Granath, B., Jalkesten, E., Cotgreave, I., Öberg, M., 2014. Strategic focus on 3R principles reveals major reductions in the use of animals in pharmaceutcal toxicity testing. PLos One, 9(7): e101638.
- van der Valk, J., Bieback, K., Buta, C., Cochrane, B., Dirks, W.G., Fu, J., Hickman, J.J., Hohensee, C., Kolar, R., Liebsch, M., Pistollato, F., Schulz, M., Theme, D., Weber, T., Wiest, J., Winkler, S., and Gstraunthaler, G. ALTEX Online first, 2017. Dpo: 10.14573/altex.170501 · DOI
Cited by
Sorted by citations
Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Oredsson, S., Coecke, S., van der Valk, J., & Vinken, M.
- Venue
- Toxicology in Vitro
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 57
- Pages
- 143-144
- ISSN
- 0887-2333
- Cited by
- 9
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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