Regulation of Corticosterone Secretion Is Modified by PFOS Exposure at Different Levels of the Hypothalamic-Pituitary-Adrenal axis in Adult Male Rats
Abstract
Perfluorooctane sulfonate (PFOS) is a fluorinated compound and a Persistent Organic Pollutant which can disrupt the endocrine system. This work was undertaken to evaluate the possible effects of PFOS exposure on the regulation of corticosterone secretion in adrenal and pituitary glands and at hypothalamic level in adult male rat, and to evaluate the possible morphological alterations induced by PFOS in this endocrine tissue. Adult male rats were orally treated with 0.5, 1.0, 3.0 and 6.0 mg of PFOS/kg/day for 28 days. Corticosterone, adrenocorticotropic hormone (ACTH) and corticotrophin-releasing hormone (CRH) secretion decreased in PFOS-treated rats. After PFOS exposure, relative expression of adrenocorticotropic hormone receptor (ACTHr) and proopiomelanocortin (POMC) genes was increased in adrenal and in pituitary glands, respectively; while relative expression of ACTHr and CRH genes decreased in hypothalamus with the doses of 0.5 and 1.0 mg/kg/day. PFOS treatment increased relative nitric oxide synthase 1 and 2 (NOS1 and NOS2) gene expression in the adrenal gland, and incremented superoxide dismutase activity. PFOS exposure induces a global inhibition of the hypothalamic-pituitary-adrenal (HPA) axis activity, and small morphological changes were observed in adrenal zona fasciculata cells.
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A majority of evidence for PFAS-induced endocrine disruption is at the level of circulating stress, sex, and thyroid hormones, while data regarding PFAS-associated disruption of synthesis enzymes and receptors is more limited, especially within the brain.
“A majority of evidence for PFAS-induced endocrine disruption is at the level of circulating stress, sex, and thyroid hormones, while data regarding PFAS associated disruption of synthesis enzymes and receptors is more limited, especially within the brain”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Pereiro et al., 2014
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References 83 · Cited by 42
- Authors
- Pereiro, N., Moyano, R., Blanco, A., & Lafuente, A.
- Affiliations
- Universidade de Vigo (ES)
- University of Córdoba (ES)
- Corresponding author
- Lafuente, A.
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 230
- Issue
- 2
- Pages
- 252-262
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W1992073015
- Cited by
- 42
- References
- 83
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 2
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Innovation, Spain (AGL2009-09061, INCITE09 383 314 PR)
- Xunta de Galicia
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- PFOS, hypothalamic-pituitary-adrenal axis, corticosterone secretion, ACTH, corticotropin-releasing factor, ACTH receptor, proopiomelanocortin, nitric oxide synthase, superoxide dismutase, adrenal zona fasciculata, persistent organic pollutants, endocrine disruption, gene expression
- MeSH terms
- Adrenocorticotropic Hormone, Aging, Animals, Corticosterone, Dose-Response Relationship, Drug, Fluorocarbons, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Rats, Sprague-Dawley, Alkanesulfonic Acids, Rats
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