Poly(l-lactic acid) membranes: Absence of genotoxic hazard and potential for drug delivery
Abstract
The use of poly(L-lactic acid) (PLA) has been considered an important alternative for medical devices once this polyester presents biomechanical, optical and biodegradable properties. Moreover, the use of PLA results in less inflammatory reactions and more recently it has been proposed its application in drug delivery systems. Genotoxicological evaluations are considered part of the battery assays in toxicological analysis. Considering the wide applications of PLA, the present work evaluated the potential cytotoxic and genotoxic effects of PLA in CHO-K1 cells, as well as its physicochemical properties. No cytotoxic effects of PLA were detected by colorimetric tetrazolium assay (XTT) analysis, and the clonogenic survival assay showed that PLA did not disrupt the replicative cell homeostasis, neither exhibited genotoxic effects as evidenced by comet and micronucleus assays. Thermogravimetric properties of PLA were not altered after contact with cells and this film exhibited ability in absorb and release Europium(III) complex. All these data suggest genotoxicological safety of PLA for further applications in drug delivery systems.
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Following hydrolysis, the breakdown process's byproducts are changed into non-toxic byproducts that can be reduced and eliminated by regular cellular function and urine.
“Following hydrolysis, the breakdown process’s byproducts are changed into non-toxic byproducts that can be reduced and eliminated by regular cellular function and urine [87].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [87]
Cites
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816 · see citing works
Fukushima, K., & Kimura, Y. (2008) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.22712 · Cited by 120 · see citing works
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Uzun, N., Martins, T. D., Teixeira, G. M., Cunha, N. L., Oliveira, R. B., Nassar, E. J., & dos Santos, R. A.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Universidade de Franca (BR)
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 232
- Issue
- 2
- Pages
- 513-518
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W2003697177
- Cited by
- 31
- References
- 2
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo–FAPESP (2011/17935-7)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- poly(L-lactic acid), genotoxicity, cytotoxicity, drug delivery systems, biodegradable polymers, medical devices, CHO-K1 cells, clonogenic survival, comet assay, micronucleus test, europium complexes, biocompatibility
- MeSH terms
- Animals, Cell Survival, Colony-Forming Units Assay, Cricetulus, Cricetinae, Membranes, Artificial, Mutagenicity Tests, Mutagens, Polyesters, Polymers, Micronucleus Tests, CHO Cells, Drug Delivery Systems, Lactic Acid, Comet Assay
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