Derivatization for liquid chromatography-mass spectrometry
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Chemical labelling is a largely used strategy for the detection of small molecules that are not readily detected by LC-MS.
“A largely used strategy for the detection of small molecules that are not readily detected by LC-MS is “chemical labelling” (Fig. 3D).95–97”
From Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products (2024) · cites this paper as [96]
Derivatization protocols have been developed for functional groups including alcohols, phenols, ketones, aldehydes and carboxylic acids.
“Derivatization protocols have been developed for functional groups including, but not limited to alcohols, phenols, ketones, aldehydes and carboxylic acids.96,97”
From Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products (2024) · cites this paper as [96]
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References 161 · Cited by 254
- Authors
- Qi, B.-L., Liu, P., Wang, Q.-Y., Cai, W.-J., Yuan, B.-F., & Feng, Y.-Q.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Yuan, Bi-Feng
- Feng, Yu-Qi
- Venue
- TrAC Trends in Analytical Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 59
- Pages
- 121-132
- ISSN
- 0165-9936 (ISSN-L)
- OpenAlex
- W2037446268
- Cited by
- 254
- References
- 161
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 24 · 2023: 23 · 2022: 18 · 2021: 21 · 2020: 20 · 2019: 27 · 2018: 22 · 2017: 27 · 2016: 16 · 2015: 17 · 2014: 3 · 2013: 1
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- TrAC Trends in Analytical Chemistry (publishedVersion)
- Funders
- National Natural Science Foundation of China (91217309, 91017013, 21228501, 21205091)
- Fundamental Research Funds for the Central Universities
- National Key Research and Development Program of China (2013CB910702, 2012CB720601)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- derivatization, derivatization reagents, reaction mechanism, ionization efficiency, structure elucidation, chromatographic separation, peptide analysis, protein analysis, metabolite analysis, environmental analysis, pharmaceutical analysis, food safety, mass spectrometry imaging
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