Oncogene-Directed Alterations in Cancer Cell Metabolism
Open accessAbstract
Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns in cancer cells is only beginning to be appreciated. Recent studies show that oncogenes directly regulate critical metabolic enzymes and metabolic signaling pathways. Here, we present evidence for oncogene-directed cancer metabolic regulation and discuss the importance of identifying underlying mechanisms that can be targeted for developing precision cancer therapies.
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Oncogenes including RAS can promote aerobic glycolysis and activate anabolic pathways.
“The recognition that oncogenes, including RAS, can promote aerobic glycolysis, commonly known as the Warburg effect, and activate anabolic pathways 22,23, has increased efforts to understand the molecular underpinnings of altered metabolism in cancer24.”
From The metabolic landscape of RAS-driven cancers from biology to therapy (2021) · cites this paper as [22]
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References 95 · Cited by 169
- Authors
- Nagarajan, A., Malvi, P., & Wajapeyee, N.
- Affiliations
- Yale University (US)
- Yale Cancer Center (US)
- Corresponding author
- Wajapeyee, Narendra
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 2
- Issue
- 7
- Pages
- 365-377
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- PMC
- PMC5096652
- OpenAlex
- W2471848072
- Cited by
- 169
- References
- 95
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 26 · 2023: 16 · 2022: 22 · 2021: 17 · 2020: 19 · 2019: 25 · 2018: 20 · 2017: 9
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001863)
- National Cancer Institute (R01CA200919, R21CA197758, R21CA195077, R01CA196566, R21CA191364, R41CA195908)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- oncogenes, cancer metabolism, metabolic reprogramming, metabolic enzymes, metabolic signaling pathways, tumor growth, precision cancer therapy, metabolic targeting
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Neoplasms, Oncogenes, Metabolic Networks and Pathways, Molecular Targeted Therapy
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