The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recharging aged-CAR with NAD+ to boost immunotherapy
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The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Interventions such as NAD⁺ supplementation and costimulatory domain optimization have been proposed to enhance T-cell durability and prevent dysfunction70,71.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [71]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Emerging evidence links CAR-T cell aging to therapeutic failure, identifying cellular senescence as a primary mechanism of relapse.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [71]
Experimental — accuracy not yet measured
Self-check
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Citations
Cites
Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice
Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S., & Imai, S.-I. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.015 · Cited by 407
Flagged first, then by citations
Research works printed but not linked: 9
- Fan, 2024, Metabolic footprint and logic through the T cell life cycle, Curr. Opin. Immunol., 91, 10.1016/j.coi.2024.102487 · DOI
- Xu, 2019, A metabolism toolbox for CAR T therapy, Front. Oncol., 9, 322, 10.3389/fonc.2019.00322 · DOI
- Hope, 2025, Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure, Nat. Cancer, 10.1038/s43018-025-00982-7 · DOI
- Wang, 2021, NAD(+) supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells, Cell Rep., 36, 10.1016/j.celrep.2021.109516 · DOI
- Noll, 2023, Beyond youth: understanding CAR T cell fitness in the context of immunological aging, Semin. Immunol., 70, 10.1016/j.smim.2023.101840 · DOI
- Mishra, 2024, The intersection of frailty and metabolism, Cell Metab., 36, 893, 10.1016/j.cmet.2024.03.012 · DOI
- Lee, 2021, Intersection of immunometabolism and immunosenescence during aging, Curr. Opin. Pharmacol., 57, 107, 10.1016/j.coph.2021.01.003 · DOI
- Ye, 2024, NAD(+) supplementation prevents STING-induced senescence in CD8(+) T cells by improving mitochondrial homeostasis, J. Cell. Biochem., 125, 10.1002/jcb.30522 · DOI
- Navas, 2021, NAD(+) metabolism, stemness, the immune response, and cancer, Signal Transduct. Target. Ther., 6, 2, 10.1038/s41392-020-00354-w · DOI
Cited by
Sorted by citations
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
Zhang, W., Song, S., Zhang, Y., Pan, Y., Hu, D., & Wang, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00355-z · Cited by 6
Self-citation
Metadata
- Authors
- Fan, G., Wang, Y., & Wang, R.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2025-08
- Volume
- 11
- Issue
- 8
- Pages
- 711-712
- ISSN
- 2405-8033
- PMC
- PMC12210223
- Cited by
- 4
- References
- 1
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 376 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- National Institutes of Health
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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