The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Recent Fascinating Aspects of the CuAAC Click Reaction
Abstract
CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our mechanistic understanding and in the absence of oxygen, CuAAC reactions are superior even in bioligation chemistry. The catalytic cycle provides an organometallic intermediate reacting through electrophilic or oxidative escape valves resulting in trisubstituted 1,2,3-triazoles and allowing CuAAC-multicomponent reactions. The ease of CuAAC provides new pathways in the development of exquisitely selective macrocyclic protein–protein interaction inhibitors (PPIs) and enzyme inhibitors as putative novel classes of pharmaceuticals.
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Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
Self-citationCu-Catalyzed Azide−Alkyne Cycloaddition
Meldal, M., & Tornøe, C. W. (2008) · Chemical Reviews · doi:10.1021/cr0783479 · Cited by 4,628
Self-citation1,3‐Dipolar Cycloadditions. Past and Future
Huisgen, R. (1963) · Angewandte Chemie International Edition in English · doi:10.1002/anie.196305651 · Cited by 2,929
Expanding the Genetic Code of Escherichia coli
Wang, L., Brock, A., Herberich, B., & Schultz, P. G. (2001) · Science · doi:10.1126/science.1060077 · Cited by 1,499
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
Bock, V. D., Hiemstra, H., & van Maarseveen, J. H. (2006) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200500483 · Cited by 1,452
Analysis and Optimization of Copper‐Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation
Hong, V., Presolski, S. I., Ma, C., & Finn, M. G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200905087 · Cited by 1,029
Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions
Worrell, B. T., Malik, J. A., & Fokin, V. V. (2013) · Science · doi:10.1126/science.1229506 · Cited by 894
Mechanism of the Ligand‐Free CuI‐Catalyzed Azide–Alkyne Cycloaddition Reaction
Rodionov, V. O., Fokin, V. V., & Finn, M. G. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461496 · Cited by 625
Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry
Hong, V., Steinmetz, N. F., Manchester, M., & Finn, M. G. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100272z · Cited by 432
Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions
Kennedy, D. C., McKay, C. S., Legault, M. C. B., Danielson, D. C., Blake, J. A., Pegoraro, A. F., Stolow, A., Mester, Z., & Pezacki, J. P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2083027 · Cited by 416
Cited by
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
Agrahari, A. K., Bose, P., Jaiswal, M. K., Rajkhowa, S., Singh, A. S., Hotha, S., Mishra, N., & Tiwari, V. K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00920 · Cited by 445
La Barbera, L., Mauri, E., D’Amelio, M., & Gori, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.939855 · Cited by 74
Metadata
- Authors
- Meldal, M., & Diness, F.
- Venue
- Trends in Chemistry
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 2
- Issue
- 6
- Pages
- 569-584
- ISSN
- 2589-5974 (ISSN-L)
- OpenAlex
- W3019721693
- Cited by
- 266
- References
- 89
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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