Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation

Sun, Likun; Li, Xin; Luo, Zhongchen; Li, Maohua; Liu, Hongyu; Zhu, Zhaowei; Wang, Junwei; Lu, Peng; Wang, Lunchang; Yang, Chenzi; Wang, Tun; He, Hao; Li, Ming; Shu, Chang; Li, Jiehua

doi:10.1016/j.trsl.2023.03.002

Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation

The purinergic receptor P2X7 has been established as an important mediator of inflammation and participates in a variety of cardiovascular diseases including atherosclerosis, however, its role in abdominal aortic aneurysms (AAA) remains unclear. In this study, we demonstrate that P2X7 plays essen…