Infertility with Testicular Cancer
Abstract
Testicular germ cell cancer is one of the most curable cancers. Most patients are treated during their reproductive years, making infertility a significant quality of life issue after successful treatment. This focused review evaluates the factors that contribute to infertility and specific fertility risks with the various testicular cancer treatments. Timing of patient discussions and current fertility treatments are reviewed.
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There is an ongoing effort to utilize novel treatment strategies that might result in improved clinical outcomes with fewer or less significant long-term adverse events compared to platinum-based chemotherapy.
“In this setting, there is an ongoing effort to utilize novel treatment strategies that might result in improved clinical outcomes at a cost of fewer or/and less significant long term adverse events compared to platinum-based chemotherapy [9,10,11,12].”
From The Immune Landscape and Immunotherapeutic Strategies in Platinum-Refractory Testicular Germ Cell Tumors (2024) · cites this paper as [9]
Long-term adverse effects related to chemotherapy are an aspect of TGCT treatment given patients' young age and high cure rate.
“Another aspect of the treatment for TGCTs, given the patients’ young age at diagnosis and overall high cure rate, is the long-term adverse effects related to chemotherapy.”
From The Immune Landscape and Immunotherapeutic Strategies in Platinum-Refractory Testicular Germ Cell Tumors (2024) · cites this paper as [9]
Cited by
Sorted by citations
Eisenberg, M. L., Esteves, S. C., Lamb, D. J., Hotaling, J. M., Giwercman, A., Hwang, K., & Cheng, Y.-S. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00459-w · Cited by 536 · see citing works
Evmorfopoulos, K., Marsitopoulos, K., Karachalios, R., Karathanasis, A., Dimitropoulos, K., Tzortzis, V., Zachos, I., & Vlachostergios, P. J. (2024) · Cancers · doi:10.3390/cancers16020428 · Cited by 11 · see citing works
“In this setting, there is an ongoing effort to utilize novel treatment strategies that might result in improved clinical outcomes at a cost of fewer or/and less significant long term adverse events compared to platinum-based chemotherapy [9–12].”
Background
- Authors
- Ostrowski, K. A., & Walsh, T. J.
- Affiliations
- Oregon Health & Science University (US)
- University of Washington (US)
- ORCID
- Walsh, Thomas J.
- Venue
- Urologic Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 42
- Issue
- 3
- Pages
- 409-420
- ISSN
- 0094-0143 (ISSN-L)
- OpenAlex
- W1545971240
- Cited by
- 61
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 1 · 2019: 11 · 2018: 5 · 2017: 5 · 2016: 4
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Urologic Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testicular germ cell tumors, infertility, fertility preservation, fertility-sparing treatment, cancer treatment side effects, fertility counseling
- MeSH terms
- Adaptation, Psychological, Antineoplastic Agents, Humans, Infertility, Male, Lymph Node Excision, Male, Neoplasm Staging, Neoplasms, Germ Cell and Embryonal, Orchiectomy, Quality of Life, Spermatogenesis, Testicular Neoplasms, Testis, Cryopreservation, Radiotherapy, Adjuvant, Organs at Risk, Fertility Preservation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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