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Characteristics of Men Undergoing Testosterone Replacement Therapy and Adherence to Follow-up Recommendations in Metropolitan Multicenter Health Care System
Abstract
Objective To identify the frequencies of treatment and recommended laboratory follow-up for men with low serum testosterone levels. Methods The Electronic Data Warehouse was queried to identify men of ages 18-85 years, who obtained a testing for serum total testosterone level from 2009 to 2012. The frequency of testosterone replacement therapy (TRT), patient demographics, and clinical characteristics were collected. The frequency of follow-up with serum total testosterone and complete blood count levels was documented. Results Among 9176 men who underwent testing for low testosterone levels, 3320 (36%) of them were hypogonadal with a mean serum total testosterone level of 194.3 ± 64.9 ng/dL. Of them, 17.7% men were treated with TRTs. The treatment frequency significantly increased from 8.3% in 2009 to 24% in 2012. A total of 4.8% of men of reproductive ages (age, 18-35 years) were placed on TRTs. Within 180 days of initial testing, only 40% of treated men received follow-up with liver function tests and/or complete blood count, and only 49% had a follow-up serum testosterone level. Conclusion Although the frequency of TRT is increasing, only a small percentage of hypogonadal men are actively undergoing treatment. A significant proportion of men of reproductive age are being treated with significant impacts on potential fertility. Less than half of the patients treated are being monitored appropriately after testosterone replacement. This highlights the importance of further e…
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“Of men who are treated with testosterone, nearly half do not have their testosterone levels checked after therapy commences.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [3]
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“While up to a third of men who are placed on testosterone therapy do not meet the criteria to be diagnosed as testosterone deficient”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [3]
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Metadata
- Authors
- Malik, R. D., Wang, C. E., Lapin, B., Lakeman, J. C., & Helfand, B. T.
- Affiliations
- University of Chicago Medical Center (US)
- Endeavor Health (US)
- Corresponding author
- Malik, Rena D.
- Venue
- Urology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 85
- Issue
- 6
- Pages
- 1382-1388
- ISSN
- 0090-4295 (ISSN-L)
- OpenAlex
- W2042842990
- Cited by
- 26
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- testosterone replacement therapy, hypogonadism, follow-up monitoring, medication adherence, liver function tests, complete blood count, men of reproductive age, fertility, prescribing education
- MeSH terms
- Adolescent, Adult, Aged, Androgens, Follow-Up Studies, Health Facilities, Humans, Male, Middle Aged, Testosterone, Guideline Adherence, Hormone Replacement Therapy, Young Adult
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- Malik, R. D., Wang, C. E., Lapin, B., Lakeman, J. C., & Helfand, B. T. (2015). Characteristics of Men Undergoing Testosterone Replacement Therapy and Adherence to Follow-up Recommendations in Metropolitan Multicenter Health Care System. Urology. https://doi.org/10.1016/j.urology.2015.01.027
