CoChat
Sign Up
Cited by 62Hormonal and reproductive studiesSleep and Work-Related FatigueCircadian rhythm and melatonin

Poor Sleep Quality Predicts Hypogonadal Symptoms and Sexual Dysfunction in Male Nonstandard Shift Workers

Open access
Pastuszak, Alexander W., Moon, Young M., Scovell, Jason, Badal, Justin, Lamb, Dolores J., Link, Richard E., Lipshultz, Larry I.·2017·Urology
DOI 10.1016/j.urology.2016.11.033PMC PMC5710003
Open this paper in CoChat — free account

Abstract

Objective To investigate the impact of sleep quality in hypogonadal symptoms and sexual function in men working nonstandard shifts. Materials and methods Men treated at a single andrology clinic between July and October 2014 completed questionnaires assessing sleep quality, hypogonadal symptoms (Androgen Deficiency in the Aging Male [ADAM/qADAM]), and sexual function (International Index of Erectile Function [IIEF]). Serum hormone levels were assessed at the time of survey completion. Results One hundred eighty-two men were identified as working nonstandard shifts (work that starts before 7 a.m. or after 2 p.m., rotates, or regularly includes hours outside of the standard 7 a.m. to 6 p.m. workday) with a mean ± SD age of 41.1 ± 10.8 years. Of men working nonstandard shifts, those with better sleep quality had fewer hypogonadal symptoms and better sexual function. Multivariate regression analysis revealed significant linear associations between sleep quality and qADAM score (P = .008), positive ADAM responses (P = .003), and IIEF score (P = .0004). When comparing individual groups, men who were "very satisfied" (n = 60) with sleep quality had higher qADAM scores than men who were "somewhat dissatisfied" (P = .02), and men who were "very dissatisfied" had significantly lower IIEF scores than men who were "very satisfied" (P = .001) and "somewhat satisfied" (P = .005). No associations between sleep quality and mean serum testosterone, free testosterone, estrogen, dehydroepiandrosterone, follicle-stimulating hormone, and luteinizing hormone levels were observed. Conclusion Men who work nonstandard shifts and have poor sleep quality are at increased risk for hypogonadal symptoms and sexual dysfunction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.urology.2016.11.033

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Self-reported sleep quality has a linear relationship with symptoms of testosterone deficiency as quantified by the ADAM questionnaire.

    “Pastuszak et al. noted a linear relationship between self-reported sleep quality and symptoms of testosterone deficiency as quantified by the Androgen Deficiency in the Aging Male (ADAM) questionnaire (22).”

    From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [22]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 34 · Cited by 62

Research works printed but not linked: 23

  1. [1]Presser HB Job, family, and gender: Determinants of nonstandard work schedules among employed Americans in 1991 Demography 1995 32 577 598 8925948
  2. [2]Wright KP Jr Bogan RK Wyatt JK Shift work and the assessment and management of shift work disorder (SWD) Sleep medicine reviews 2013 17 41 54 22560640
  3. [3]Vogel M Braungardt T Meyer W Schneider W The effects of shift work on physical and mental health Journal of neural transmission 2012 119 1121 1132 22488445
  4. [4]Froy O Metabolism and circadian rhythms--implications for obesity Endocrine reviews 2010 31 1 24 19854863
  5. [5]Axelsson J Åkerstedt T Kecklund G Lindqvist A Attefors R Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle Journal of Applied Physiology 2003 95 2099 2105 12882998
  6. [7]Patel SR Hu FB Short sleep duration and weight gain: a systematic review Obesity 2008 16 643 653 18239586 PMC2723045
  7. [9]Mullington JM Simpson NS Meier-Ewert HK Haack M Sleep loss and inflammation Best practice & research. Clinical endocrinology & metabolism 2010 24 775 784 21112025 PMC3548567
  8. [10]Gacci M Vignozzi L Sebastianelli A Metabolic syndrome and lower urinary tract symptoms: the role of inflammation Prostate cancer and prostatic diseases 2013 16 101 106 23165431
  9. [13]Wang C Nieschlag E Swerdloff R Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations Journal of andrology 2009 30 1 9 18772485
  10. [14]Wu FC Tajar A Beynon JM Identification of late-onset hypogonadism in middle-aged and elderly men The New England journal of medicine 2010 363 123 135 20554979
  11. [16]Moskovic DJ Araujo AB Lipshultz LI Khera M The 20-year public health impact and direct cost of testosterone deficiency in U.S. men J Sex Med 2013 10 562 569 23035926
  12. [18]Harman SM Metter EJ Tobin JD Pearson J Blackman MR Baltimore Longitudinal Study of A Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging The Journal of clinical endocrinology and metabolism 2001 86 724 731 11158037
  13. [19]Seftel A Male hypogonadism. Part I: Epidemiology of hypogonadism International journal of impotence research 2006 18 115 120 16193071
  14. [20]Pastuszak AW Current Diagnosis and Management of Erectile Dysfunction Current Sexual Health Reports 2014 6 164 176 25878565 PMC4394737
  15. [21]Touitou Y Motohashi Y Reinberg A Effect of shift work on the night-time secretory patterns of melatonin, prolactin, cortisol and testosterone European journal of applied physiology and occupational physiology 1990 60 288 292 2357985
  16. [22]Mohamed O Freundlich R Dakik H The quantitative ADAM questionnaire: a new tool in quantifying the severity of hypogonadism International journal of impotence research 2010 22 20 24 19657348 PMC2834355
  17. [23]Rosen RC Riley A Wagner G Osterloh IH Kirkpatrick J Mishra A The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction Urology 1997 49 822 830 9187685
  18. [24]Mirick DK Bhatti P Chen C Nordt F Stanczyk FZ Davis S Night shift work and levels of 6-sulfatoxymelatonin and cortisol in men Cancer Epidemiology Biomarkers & Prevention 2013 22 1079 1087 PMC4772962 23563887
  19. [26]Luboshitzky R Zabari Z Shen-Orr Z Herer P Lavie P Disruption of the Nocturnal Testosterone Rhythm by Sleep Fragmentation in Normal Men The Journal of Clinical Endocrinology & Metabolism 2001 86 1134 1139 11238497
  20. [28]Luboshitzsky R Herer P Levi M Shen-Orr Z Lavie P Relationship Between Rapid Eye Movement Sleep and Testosterone Secretion in Normal Men Journal of Andrology 1999 20 731 737 10591612
  21. [29]Kang JI Ham BK Oh MM Kim JJ Moon DG Correlation between serum total testosterone and the AMS and IIEF questionnaires in patients with erectile dysfunction with testosterone deficiency syndrome Korean journal of urology 2011 52 416 420 21750754 PMC3123819
  22. [30]Boloña ER Uraga MV Haddad RM Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials Mayo Clinic Proceedings 82 Elsevier 2007 20 28 17285782
  23. [31]Goh VHH Tong TYY Sleep, sex steroid hormones, sexual activities, and aging in Asian men Journal of andrology 2010 31 131 137 19684340

Authors
Pastuszak, A. W., Moon, Y. M., Scovell, J., Badal, J., Lamb, D. J., Link, R. E., & Lipshultz, L. I.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Pastuszak, Alexander W.
ORCID
Venue
Urology
Publisher
Elsevier BV
Published
2017-04
Volume
102
Pages
121-125
ISSN
0090-4295 (ISSN-L)
DOI
10.1016/j.urology.2016.11.033
PMC
PMC5710003
OpenAlex
W2561071887
Cited by
62
References
34
Citations by year
2025: 4 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 6
FWCI
5.36
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Urology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (T32GM088129)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep quality, hypogonadism, sexual dysfunction, erectile function, testosterone, shift workers, men's health
MeSH terms
Shift Work Schedule, Adult, Humans, Hypogonadism, Male, Middle Aged, Occupational Diseases, Quality of Life, Sexual Dysfunction, Physiological, Sleep, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review