The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65
Abstract
Studies have demonstrated that active-specific immunotherapy has potential for controlling mammary tumor progression. Human chorionic gonadotropin (hCG) is expressed and extremely sensitive, easily detectable and highly correlated with breast cancer. We developed a gene vaccine using a plasmid vector to deliver the six copies of 10-amino acid residues of beta-hCG 109-118 and beta hCG C-terminal 37-amino acid (CTP37). BALB/c female mice were immunized with a combination of pCR-HBc-X6-betahCGCTP37 DNA vaccine and HSP-X6-betahCGCTP37 protein vaccine. pCR-HBc-X6-betahCGCTP37 DNA vaccine were injected intramuscularly three times, on days -46,-25 and -11 and HSP-X6-betahCGCTP37 protein were applied two times, 21 and 14 days before tumor cell challenge. We assessed a combined DNA and protein vaccine for its effect of against murine EMT6 mammary tumor cells. In this study, animals vaccinated DNA vaccination boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65 induced higher avidity antibodies and effectively inhibited the growth of tumor, compared with treatment using DNA alone or BCG priming HSP-X6-betahCGCTP37 protein boosting. The data presented demonstrate that improve immunogenicity of DNA vaccination by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65, which should prove useful in the development of new DNA vaccine against growth factors for cancer immunotherapy.
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“In the case of CRC, numerous tumor-associated antigens have been identified and utilized in order to target MHC class I. Among these antigens are carcinoembryonic antigen (CEA), mucin-1, squamous cell carcinoma antigen recognized by T cells 3 (SART3), β-human chorionic gonadotropin (β-hCG), Survivin-2B, and p53 [153,154].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [153]
Citations
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Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37
Metadata
- Authors
- Yi, H., Rong, Y., Yankai, Z., Wentao, L., Hongxia, Z., Jie, W., Rongyue, C., Taiming, L., & Jingjing, L.
- Affiliations
- China Pharmaceutical University (CN)
- Corresponding author
- Jingjing, Liu
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2006-03-24
- Volume
- 24
- Issue
- 14
- Pages
- 2575-2584
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2057029972
- Cited by
- 31
- References
- 31
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2014: 3 · 2012: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Government of Jiangsu Province
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- DNA vaccine, breast cancer, human chorionic gonadotropin, hsp65, mycobacterial heat shock protein, active specific immunotherapy, cancer immunotherapy
- MeSH terms
- Animals, Antibodies, Neoplasm, Bacterial Proteins, Breast Neoplasms, Carrier Proteins, Chorionic Gonadotropin, Humans, Immunotherapy, Mycobacterium, Repetitive Sequences, Nucleic Acid, Vaccination, Protein Structure, Tertiary, Chaperonins, Chaperonin 60, Vaccines, DNA, Cancer Vaccines, Cell Line, Tumor, Mice
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