The DOI matches its Crossref record.
Exposure to heat and freezing in the vaccine cold chain in Thailand
Abstract
This study investigated exposure to heat and freezing of vaccines used in Thailand's National Immunization Program. Cold chain temperatures on 48 randomly selected shipment routes nationwide were monitored. Measles and hepatitis B vaccines were despatched with recording devices and subsequently tested. The study found that extremes of cold appear to be the more significant problem. Heat exposure was relatively brief and not at very high temperatures, so vaccine deterioration was unlikely, as was confirmed by measles vaccine testing. Exposure to temperatures below -0.5 degrees C was widespread, which would be expected to damage hepatitis B vaccine, but shake tests did not detect damage.
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As much as 37% of vaccines are exposed to temperatures below the recommended range in lower-income countries.
“As much as 37% of vaccines are exposed to temperatures below the recommended range in lower-income countries, making this a critical issue to address.7–13”
From Using Data to Keep Vaccines Cold in Kenya: Remote Temperature Monitoring With Data Review Teams for Vaccine Management (2019) · cites this paper as [8]
Exposure to temperature extremes within vaccine supply chains is relatively common in both developed and developing countries.
“A number of studies have shown that exposure to temperature extremes within vaccine supply chains is relatively common in both developed and developing countries.”
From Using Data to Keep Vaccines Cold in Kenya: Remote Temperature Monitoring With Data Review Teams for Vaccine Management (2019) · cites this paper as [8]
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Research works printed but not linked: 10
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Cited by
Sorted by citations
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Ashok, A., Brison, M., & LeTallec, Y. (2017) · Vaccine · doi:10.1016/j.vaccine.2016.08.045 · Cited by 308
Lutukai, M., Bunde, E. A., Hatch, B., Mohamed, Z., Yavari, S., Some, E., Chweya, A., Kania, C., Ross, J. C., Keddem, C., et al. (2019) · Global Health: Science and Practice · doi:10.9745/ghsp-d-19-00157 · Cited by 17
Metadata
- Authors
- Techathawat, S., Varinsathien, P., Rasdjarmrearnsook, A., & Tharmaphornpilas, P.
- Affiliations
- Ministry of Public Health (TH)
- Corresponding author
- Tharmaphornpilas, Piyanit
- ORCID
- Techathawat, Sirirat
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 25
- Issue
- 7
- Pages
- 1328-1333
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2106278164
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 2 · 2014: 8 · 2013: 3 · 2012: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pharmaceutical Quality and Counterfeiting
- Health Sciences › Health Professions › Medical Laboratory Technology › Quality and Safety in Healthcare
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Supply Chain Traceability
- Keywords
- vaccine cold chain, vaccine storage temperature, heat exposure, freezing, measles vaccine, hepatitis B vaccine, National Immunization Program, Thailand
- MeSH terms
- Cold Temperature, Data Collection, Drug Storage, Freezing, Hot Temperature, Measles Vaccine, Thailand, Vaccines, Hepatitis B Vaccines
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