Meningococcal C conjugate vaccine: the experience in England and Wales
Abstract
Meningococcal C conjugate vaccine was introduced in the UK in November 1999 together with a comprehensive meningococcal surveillance strategy to support and inform the vaccine programme. These surveillance data have provided important information on the long-term effectiveness of the programme, through direct and indirect protection, and on the prevalent serotypes and serosubtypes causing invasive meningococcal infection subsequent to vaccine introduction. The MCC immunization programme has been extremely successful in controlling serogroup C disease and continues to be evaluated. The aim of this paper is to review the experiences in England and Wales over the past 9 years.
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Reductions in incidence of >97% were seen within a decade after MenC vaccination.
“Reductions in incidence of >97% were seen within a decade.12”
From Community-acquired acute bacterial meningitis in adults: a clinical update (2019) · cites this paper as [12]
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References 81 · Cited by 168
- Authors
- Campbell, H., Borrow, R., Salisbury, D., & Miller, E.
- Affiliations
- Manchester Royal Infirmary (GB)
- Corresponding author
- Campbell, Helen
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 27
- Pages
- B20-B29
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2049865589
- Cited by
- 168
- References
- 81
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 8 · 2012: 16
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- meningococcal C vaccine, serogroup C meningococcal disease, meningococcal surveillance, vaccine effectiveness, serotype distribution, immunization programs, England and Wales
- MeSH terms
- England, Humans, Meningitis, Meningococcal, Population Surveillance, Wales, Meningococcal Vaccines, Neisseria meningitidis, Serogroup C
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