Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination
Abstract
Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules.
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Infants whose HepB vaccination schedule was supplemented with probiotics demonstrated enhanced HBsAb IgG production vs placebo.
“Furthermore, in a study published in 2010 infants whose HepB vaccination schedule (two doses monovalent + one dose combination) was supplemented with probiotics (during 1st 6 months of life) demonstrated enhanced HepB virus surface antibody (HBsAb) immunoglobulin G production vs placebo (Soh et al., 2010).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Soh et al., 2010
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References 21 · Cited by 78
- Authors
- Soh, S. E., Ong, D. Q. R., Gerez, I., Zhang, X., Chollate, P., Shek, L. P.-C., Lee, B. W., & Aw, M.
- Affiliations
- National University Health System (SG)
- Singapore Clinical Research Institute (SG)
- Corresponding author
- Aw, Marion
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 28
- Issue
- 14
- Pages
- 2577-2579
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2083349178
- Cited by
- 78
- References
- 21
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, infant immunization, hepatitis B vaccine, antibody response, IgG, infant immunization schedule, vaccine immunogenicity
- MeSH terms
- Female, Hepatitis B Antibodies, Humans, Immunoglobulin G, Infant, Infant, Newborn, Male, Placebos, Diphtheria-Tetanus-Pertussis Vaccine, Hepatitis B Vaccines, Haemophilus Vaccines, Probiotics
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