Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy
Open accessAbstract
Allergen-specific immunotherapy is the only treatment shown to induce antigen-specific regulatory T (Treg) cells and peripheral tolerance to restore human homeostasis. Specific probiotic strains are valid candidates to improve the allergen-specific tolerance, since they are able to generate Treg cells from naïve precursors. We recently reported that exposing dendritic cells (DCs) to Bifidobacterium bifidum LMG13195 in vitro induced the polarization of naïve T cells into functional Treg cells. In the present study, we evaluated the ability of DCs exposed to different B. bifidum subcellular fractions to promote Treg differentiation. We found that DCs exposed to B. bifidum LMG13195 membrane vesicles most strongly promoted differentiation of functional CD25(high)FOXP3(high)CD127(-/low) Treg cells as well as induced the highest IL-10 levels respect to the proinflammatory cytokines IFNγ, TNFα and IL-17. Our results suggest the potential use of B. bifidum LMG13195 membrane vesicles as a safe and clinically effective adjuvant for immunotherapy.
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Each Bifidobacterium species appeared to elicit different immune effects on the host, noteworthy being the ability of B. bifidum to expand the T-regulatory response, which may be relevant for its use in chronic inflammatory diseases.
“Each Bifidobacterium species appeared to elicit different immune effects on the host, noteworthy being the ability of B. bifidum to expand the T-regulatory response, which may be relevant for its use in chronic inflammatory diseases (104).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [104]
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References 22 · Cited by 101
- Authors
- López, P., González-Rodríguez, I., Sánchez, B., Gueimonde, M., Margolles, A., & Suárez, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Oviedo (ES)
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 30
- Issue
- 5
- Pages
- 825-829
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2084730809
- Cited by
- 101
- References
- 22
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- European Union FEDER funds and the Spanish Plan Nacional de I+D (AGL2007-61805, AGL2010-14952)
- Spanish Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- Bifidobacterium bifidum, membrane vesicles, regulatory T cells, allergen immunotherapy, probiotics, dendritic cells, adjuvants, Foxp3, IL-10, subcellular fractions, peripheral tolerance
- MeSH terms
- Adjuvants, Immunologic, Allergens, Bifidobacterium, Dendritic Cells, Humans, Hypersensitivity, Immunotherapy, Interferon-gamma, Tumor Necrosis Factor-alpha, Interleukin-10, Interleukin-17, Secretory Vesicles, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit
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