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Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura

Esen, Meral, Mordmüller, Benjamin, de Salazar, Pablo Martinez, Adegnika, Ayola Akim, Agnandji, Selidji Todagbe, Schaumburg, Frieder, Hounkpatin, Aurore Bouyoukou, Brückner, Sina, Theisen, Michael, Bélard, Sabine, Ngoa, Ulysse Ateba, Issifou, Saadou, Yazdanbakhsh, Maria, Kremsner, Peter G.·2012·Vaccine
DOI 10.1016/j.vaccine.2012.10.026
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Abstract

Background Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. Methods Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. Results Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. Conclusions Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.

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Research works printed but not linked: 17

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Metadata

Authors
Esen, M., Mordmüller, B., de Salazar, P. M., Adegnika, A. A., Agnandji, S. T., Schaumburg, F., Hounkpatin, A. B., Brückner, S., Theisen, M., Bélard, S., Ngoa, U. A., Issifou, S., Yazdanbakhsh, M., & Kremsner, P. G.
Venue
Vaccine
Publisher
Elsevier BV
Published
2012-12
Volume
30
Issue
52
Pages
7621-7624
ISSN
0264-410X
DOI
10.1016/j.vaccine.2012.10.026
Cited by
52
References
0
Language
en
Licence
Funders
  • European and Developing Countries Clinical Trials Partnership (IP.2007.31100.001)
  • Bundesministerium für Bildung und Forschung (01KA0804, 01KA1009)

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