Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA

Doritchamou, Justin; Bigey, Pascal; Nielsen, Morten Agertoug; Gnidehou, Sédami; Ezinmegnon, Sem; Burgain, Aurore; Massougbodji, Achille; Deloron, Philippe; Salanti, Ali; Ndam, Nicaise Tuikue

doi:10.1016/j.vaccine.2013.07.072

Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA

BACKGROUND VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating placental malaria (PM). The N-terminal part of VAR2CSA that contains the binding site to placental chondroitin sulfate A (C…