Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licenced in veterinary medicine
Open accessAbstract
The susceptibility of Streptococcus suis strains (n=384) isolated from diseased pigs in seven European countries to 10 antimicrobial agents was determined. For that purpose a microbroth dilution method was used according to CLSI recommendations. The following antimicrobial agents were tested: ceftiofur, cefquinome, enrofloxacin, florfenicol, gentamicin, penicillin, spectinomycin, tetracycline, tilmicosin and trimethoprim/sulphamethoxazole. Using breakpoints established by CLSI for veterinary pathogens, all strains were susceptible to ceftiofur, florfenicol, enrofloxacin and penicillin. MIC-90 values of these antibiotics were < or = 0.03, 0.5, 2 and < or = 0.13 microg/mL, respectively. A low degree of resistance was observed for gentamicin (1.3%), spectinomycin (3.6%) and trimethoprim/sulphamethoxazole (6.0%). MIC-90 values of these antibiotics were 8, 16 and 2 microg/mL, respectively. A high level of resistance was observed for tetracycline (75.1%). A MIC-90 value of 64 microg/mL was found for this antibiotic. Serotype-associated differences in MIC-90 values were observed for tetracycline, tilmicosin and trimethoprim/suphamethoxazole.
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Our findings of 0.0 to 3.0% resistance to five compounds in S. suis are compatible with older results from seven EU countries.
“The above results together with our findings (0.0 to 3.0% resistance to five compounds) are compatible with the older results of S. suis isolates from seven EU countries (Wisselink et al., 2006).”
From Pan-European analysis shows stable, low antimicrobial resistance in most bovine and porcine respiratory tract pathogens (2026) · cites this paper as Wisselink et al., 2006
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de Jong, A., Temmerman, R., Rose, M., Simjee, S., El Garch, F., & on behalf of the VetPath Study Group (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1745115 · Cited by 3 · see citing works
- Authors
- Wisselink, H. J., Veldman, K. T., Van den Eede, C., Salmon, S. A., & Mevius, D. J.
- Affiliations
- Wageningen University & Research (NL)
- Pfizer (United States) (US)
- Corresponding author
- Wisselink, Henk J.
- Venue
- Veterinary Microbiology
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 113
- Issue
- 1-2
- Pages
- 73-82
- ISSN
- 0378-1135 (ISSN-L)
- OpenAlex
- W2117926251
- Cited by
- 80
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Veterinary Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Streptococcus suis, antimicrobial susceptibility, antimicrobial resistance, pigs, tetracycline resistance, tilmicosin, trimethoprim-sulfamethoxazole, ceftiofur, enrofloxacin, florfenicol, veterinary antibiotics, minimum inhibitory concentration
- MeSH terms
- Animals, Anti-Infective Agents, Europe, Microbial Sensitivity Tests, Serotyping, Streptococcal Infections, Swine, Swine Diseases, Streptococcus suis, Drug Resistance, Bacterial
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