Identification and characterization of P2-like bacteriophages of Yersinia pestis
Open accessAbstract
Yersinia pestis is the cause of plague, historically known as the "Black Death". Marmota himalayana in the Qinghai-Tibet Plateau (QTP) natural plague focus is the primary host in China. Although several phages originating from Y. pestis have been characterized. This is the first report of isolation of P2-like phages of Y. pestis from M. himalayana. In this study, the isolation and characterization of three P2-like phages of Y. pestis were reported, which were named as vB_YpM_22, vB_YpM_46 and vB_YpM_50. Comparative genome analysis revealed that vB_YpM_22, vB_YpM_46 and vB_YpM_50 are members of the nonlambdoid P2 family, and are highly similar and collinear with enterobacteriophage P2, plague diagnostic phage L-413C and enterobacteriophage fiAA91-ss. The role of LPS core structure of Y. pestis in the phages' receptor was pinpointed. The findings of this study contribute an advance in our current knowledge of Y. pestis phages and will also play a key role in understanding the evolution of Y. pestis phages.
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The three complete prophages found in E. coli 5C (phage_Escher_HK639, phage_Entero_HK629, and phage_Entero_fiAA91) are not dangerous for humans or animals.
“The second, the phage HK629, is also considered not dangerous for humans or animals. It is not inherently present in all E. coli strains, and it can integrate into the bacterial genome under certain conditions [140]. The third, the phage fiAA91, is not dangerous for humans or animals as well, showing similar features as HK629 [141].”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [141]
Section 3.6 (Genomic features; page unavailable) mentions fiAA91-ss only as a phage with a gene arrangement similar to the Y. pestis phages studied. Our copy does not assess whether fiAA91 is dangerous to humans or animals or compare it with HK629; searches for safety and HK629 found no such passage. (LLM, conf=0.78)
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References 37 · Cited by 11
Research works printed but not linked: 2
- Galimand, M., Guiyoule A. Fau -Gerbaud, G., Gerbaud G. Fau -Rasoamanana, B., Rasoamanana B. Fau -Chanteau, S., Chanteau S. Fau -Carniel, E., Carniel E. Fau - Courvalin, P., Courvalin, P., 1997, Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N Engl J Med. 337(10), 677-680.
- Guiyoule, A., Gerbaud G. Fau -Buchrieser, C., Buchrieser C. Fau -Galimand, M., Galimand M. Fau -Rahalison, L., Rahalison L. Fau -Chanteau, S., Chanteau S. Fau - Courvalin, P., Courvalin P. Fau -Carniel, E., Carniel, E., 2001, Transferable plasmid- mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.Emerg Infect Dis. 7(1), 43-48.
- Authors
- Qi, Z., Meng, B., Wei, X., Li, X., Peng, H., Li, Y., Feng, Q., Huang, Y., Zhang, Q., Xu, X., Zhao, H., Yang, X., Wang, C., & Zhao, X.
- Affiliations
- Qinghai Institute for Endemic Diease Prevention and Control (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Corresponding author
- Wang, Changjun
- Zhao, Xiangna
- ORCID
- Venue
- Virus Research
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 322
- Pages
- 198934
- ISSN
- 0168-1702 (ISSN-L)
- OpenAlex
- W4296334245
- Cited by
- 11
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Virus Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Beijing Municipal Natural Science Foundation (5202027)
- National Major Science and Technology Projects of China (2018ZX10712001-12-2)
- Topics
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
- Keywords
- Yersinia pestis, Marmota himalayana, phage isolation, phage genome comparison, phage receptor, plague, Tibetan Plateau, phage evolution
- MeSH terms
- Bacteriophages, China, Humans, Plague, Yersinia pestis, Tibet
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