Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients

Thieme, Constantin J.; Anft, Moritz; Paniskaki, Krystallenia; Blazquez-Navarro, Arturo; Doevelaar, Adrian; Seibert, Felix S.; Hoelzer, Bodo; Konik, Margarethe Justine; Berger, Marc Moritz; Brenner, Thorsten; Tempfer, Clemens; Watzl, Carsten; Meister, Toni L.; Pfaender, Stephanie; Steinmann, Eike; Dolff, Sebastian; Dittmer, Ulf; Westhoff, Timm H.; Witzke, Oliver; Stervbo, Ulrik; Roch, Toralf; Babel, Nina

doi:10.1016/j.xcrm.2020.100092

Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients

Summary T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe, and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of a…