LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

Hagemann, Christoffer A.; Jensen, Malene S.; Holm, Stephanie; Gasbjerg, Lærke S.; Byberg, Sarah; Skov-Jeppesen, Kirsa; Hartmann, Bolette; Holst, Jens J.; Dela, Flemming; Vilsbøll, Tina; Christensen, Mikkel B.; Holst, Birgitte; Knop, Filip K.

doi:10.1016/j.xcrm.2022.100582

LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

Summary The gastric hormone ghrelin stimulates food intake and increases plasma glucose through activation of the growth hormone secretagogue receptor (GHSR). Liver-expressed antimicrobial peptide 2 (LEAP2) has been proposed to inhibit actions of ghrelin through inverse effects on GHSR activity. …