The female protective effect against autism spectrum disorder

Wigdor, Emilie M.; Weiner, Daniel J.; Grove, Jakob; Fu, Jack M.; Thompson, Wesley K.; Carey, Caitlin E.; Baya, Nikolas; van der Merwe, Celia; Walters, Raymond K.; Satterstrom, F. Kyle; Palmer, Duncan S.; Rosengren, Anders; Bybjerg-Grauholm, Jonas; Hougaard, David M.; Mortensen, Preben Bo; Daly, Mark J.; Talkowski, Michael E.; Sanders, Stephan J.; Bishop, Somer L.; Børglum, Anders D.; Robinson, Elise B.

doi:10.1016/j.xgen.2022.100134

The female protective effect against autism spectrum disorder

Autism spectrum disorder (ASD) is diagnosed 3-4 times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common, inherited genetic risk for ASD are less studied. Leveraging the nationally rep…